HTR3C

5-hydroxytryptamine receptor 3C (5-HT3-C) (5- · Q8WXA8 · HTR3C on Sugi Atlas →

67,765 patent compounds predicted against HTR3C, 45,107 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Tropisetron (SCHEMBL18297)	1.00	7/20
Tropisetron (SCHEMBL18299)	1.00	7/20
Tropisetron (SCHEMBL133873)	0.98	7/20
Dolasetron (SCHEMBL42063)	0.72	7/20
Dolasetron (SCHEMBL42064)	0.72	7/20
Dolasetron (SCHEMBL42065)	0.72	7/20
Dolasetron (SCHEMBL41145)	0.65	7/20
Dolasetron (SCHEMBL41146)	0.65	7/20
Mirisetron (SCHEMBL194840)	0.59	7/20
Mirisetron (SCHEMBL194841)	0.59	7/20
Mirisetron (SCHEMBL121861)	0.55	6/20
Mirisetron (SCHEMBL121862)	0.55	6/20
Phenylpiperazine (SCHEMBL24889)	1.00	5/20
Phenylpiperazine (SCHEMBL55125)	1.00	5/20
SCHEMBL166140	1.00	5/20
SCHEMBL232655	0.61	5/20
SCHEMBL59331	0.61	5/20
SCHEMBL164098	0.56	5/20
SCHEMBL221254	0.55	5/20
Noxiptiline (SCHEMBL49824)	0.52	5/20

Clinical trials — most relevant to HTR3C by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Medication, Weight Gain and GI Hormones	PHASE4	COMPLETED
Cariprazine Versus Placebo for Social Anxiety Disorder	PHASE4	COMPLETED
Effectiveness of Cariprazine Monotherapy for Treatment of Major Depressive Disorder	PHASE4	NOT_YET_RECRUITING
Clinical Neurobiology of Serotonin and Addiction	PHASE2/PHASE3	COMPLETED
Study to Evaluate AD04 in Adults With Alcohol Use Disorder (AUD) and Selected Serotonin Transporter Polymorphisms	PHASE3	COMPLETED
Continuous Infusion of First-Generation 5-HT3 Receptor Antagonists in Combination With Dexamethasone	PHASE3	COMPLETED
5HT2CR Balance in Brain Connectivity in Cocaine Dependence	PHASE1/PHASE2	COMPLETED
Exploring Occupancy of Dopamine D3 Receptor by Buspirone in Humans Using PET	PHASE1/PHASE2	COMPLETED
Psilocybe Cubensis Mushrooms With or Without Fluoxetine for Refractory Depression	PHASE1/PHASE2	RECRUITING
Lorcaserin Intra Venous Cocaine Effects	PHASE1/PHASE2	UNKNOWN
Safety and Efficacy of MEM 3454 Versus Placebo in Patients With Mild to Moderate Alzheimer's Disease	PHASE2	COMPLETED
Buspirone, Stress, and Attentional Bias to Marijuana Cues	PHASE2	COMPLETED
The Effect of Ginger on the Incidence of Postoperative Nausea and Vomiting	PHASE2	COMPLETED
The Neurobiological Effect of 5-HT2AR Modulation	PHASE1	RECRUITING
PET Imaging of Brain 5-HT(1A) Receptors Using [(11)C](-)-RWAY	PHASE1	COMPLETED
The Pill Project - Oral Contraceptive and Serotonergic Brain Signaling	nan	UNKNOWN
The Efficacy of Tianeptine Versus Pregabalin on Acute and Chronic Post Mastectomy Pain After Breast Cancer Surgery.	nan	COMPLETED
Intern Health Study	nan	ENROLLING_BY_INVITATION
Evaluation of [11C]Cimbi-36 as an Agonist PET Radioligand for Imaging of 5-HT2A Receptors	nan	COMPLETED
The Role of 5-HT2A Receptor in the Perception of Self and Personal Meaning in Healthy Volunteers	nan	COMPLETED
High-Intensity Parent Intervention Program in Improving Learning and School Functioning in Latino Children With Acute Leukemia or Lymphoblastic Lymphoma	nan	ACTIVE_NOT_RECRUITING
Epigenetic and Neurochemical Correlates of Bipolar Disorder	nan	NOT_YET_RECRUITING
PET Whole Body Distribution Studies Using [11C]CUMI	nan	COMPLETED
Imaging Serotonin 5HT1A Receptors in Patients With Major Depressive Disorder	nan	WITHDRAWN
5-HT7 Receptor Implication in Inflammatory Mechanisms in Multiple Sclerosis	nan	COMPLETED
Estrogen Receptor 1 Gene Polymorphism Frequency in Fibromyalgia Syndrome	nan	COMPLETED
Investigating the Neuropsychological Effects of 5-HT2a Antagonism	nan	RECRUITING
Genetic Variants Associated With Adolescent Suicide Attempts	nan	COMPLETED
TSK (Tryptophan - Serotonin - Kynurenine) Biomarkers Assessment in Stroke	nan	COMPLETED
The Role of Sex Steroids and Serotonin Brain Dynamics in Perinatal Mental Health	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a HTR3C binder may also engage these)

Protein	Name	Similarity
HTR3E	5-hydroxytryptamine receptor 3E (5-HT3-E) (5-	0.991	landscape →
HTR3A	5-hydroxytryptamine receptor 3A	0.983	landscape →
P23979	—	0.981	P23979 →
O70212	—	0.979	O70212 →
P35563	—	0.975	P35563 →
HTR3B	5-hydroxytryptamine receptor 3B	0.960	landscape →
P13536	—	0.940	P13536 →
O97741	—	0.937	O97741 →
SCNN1A	Epithelial sodium channel subunit alpha	0.937	landscape →
P04760	—	0.937	P04760 →
P25109	—	0.935	P25109 →
Q9JJ16	—	0.935	Q9JJ16 →
H2Q5A1	—	0.934	H2Q5A1 →
P09660	—	0.934	P09660 →
Q9JHJ5	—	0.933	Q9JHJ5 →
CHRNG	Acetylcholine receptor subunit gamma	0.933	landscape →
CHRNB1	Acetylcholine receptor subunit beta	0.932	landscape →
P02715	—	0.932	P02715 →
P55270	—	0.932	P55270 →
P04758	—	0.931	P04758 →
P18916	—	0.931	P18916 →
CHRNE	Acetylcholine receptor subunit epsilon	0.930	landscape →
P02713	—	0.930	P02713 →
Q9P0L9	—	0.930	Q9P0L9 →
P37089	—	0.929	P37089 →
P20782	—	0.928	P20782 →
A2A259	—	0.927	A2A259 →
Q9R1N2	—	0.926	Q9R1N2 →
Q61180	—	0.926	Q61180 →
P09690	—	0.926	P09690 →