Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1532886 | 0.81 | KDM4E (0.39) | KDM4EMEN1ALDH1A1KMT2AHCAR2 | |
| SCHEMBL19282553 | 0.81 | HCAR2 (0.46) | KDM4EMEN1ALDH1A1KMT2AHCAR2 | |
| SCHEMBL20608764 | 0.80 | HCAR2 (0.44) | KDM4EMEN1ALDH1A1KMT2AHCAR2 | |
| SCHEMBL1025623 | 0.80 | POLB (0.44) | KDM4EMEN1ALDH1A1KMT2AHCAR2 | |
| SCHEMBL23854652 | 0.78 | KDM4E (0.36) | KDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL22289328 | 0.77 | HCAR2 (0.40) | KDM4EMEN1ALDH1A1KMT2AHCAR2 | |
| SCHEMBL1024857 | 0.76 | KDM4E (0.35) | KDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL1025144 | 0.75 | SCN2A (0.39) | MEN1KMT2AHCAR2 | |
| SCHEMBL14910266 | 0.74 | KDM4E (0.33) | KDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL1558987 | 0.74 | PDGFRB (0.37) | KDM4EMEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100048543-A1 | PYRIMIDINE COMPOUNDS HAVING TIES (TEK) INHIBITORY ACTIVITY | ASTRAZENECA AB (SE) | 2010-02-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048543-A1 | PYRIMIDINE COMPOUNDS HAVING TIES (TEK) INHIBITORY ACTIVITY | TEK, TYMP, TIE1 | KDM4E 524/4885MEN1 2463/4885ALDH1A1 2198/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.