Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DUT | P33316 | 7/20 | 0.68 |
| ▸ | TYMP | P19971 | 1/20 | 0.58 |
| ▸ | TYMS | P04818 | 4/20 | 0.48 |
| ▸ | P2RY2 | P41231 | 2/20 | 0.45 |
| ▸ | P2RY4 | P51582 | 2/20 | 0.45 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10446525 | 1.00 | DUT (0.68) | DUTTYMPTYMSP2RY2P2RY4 | |
| SCHEMBL3492644 | 1.00 | DUT (0.68) | DUTTYMPTYMSP2RY2P2RY4 | |
| SCHEMBL4422700 | 1.00 | DUT (0.68) | DUTTYMPTYMSP2RY2P2RY4 | |
| SCHEMBL3576744 | 1.00 | DUT (0.68) | DUTTYMPTYMSP2RY2P2RY4 | |
| SCHEMBL10446526 | 1.00 | DUT (0.68) | DUTTYMPTYMSP2RY2P2RY4 | |
| SCHEMBL19841219 | 0.93 | DUT (0.60) | DUTTYMPTYMSP2RY2P2RY4 | |
| SCHEMBL14403996 | 0.93 | DUT (0.60) | DUTTYMPTYMSP2RY2P2RY4 | |
| SCHEMBL13444851 | 0.93 | DUT (0.60) | DUTTYMPTYMSP2RY2P2RY4 | |
| SCHEMBL3573134 | 0.93 | DUT (0.60) | DUTTYMPTYMSP2RY2P2RY4 | |
| SCHEMBL912656 | 0.93 | DUT (0.60) | DUTTYMPTYMSP2RY2P2RY4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100075924-A1 | DUTPASE INHIBITORS | MEDIVIR AB (SE) | 2010-03-25 | — | — | US | disclosed |
| US-7601702-B2 | Dutpase Inhibitors | MEDIVIR AB (SE) | 2009-10-13 | — | — | US | disclosed |
| US-20080300216-A1 | Dutpase Inhibitors | MEDIVIR AB (SE) | 2008-12-04 | — | — | US | disclosed |
| EP-1701952-A1 | DUTPASE INHIBITORS | Medivir Aktiebolag (SE) | 2006-09-20 | — | — | EP | disclosed |
| WO-2005066160-A1 | DUTPASE INHIBITORS | MEDIVIR AB (SE) | 2005-07-21 | — | — | WO | disclosed |
| EP-0301064-B1 | 3'-AZIDO-2',3'-DIDEOXYURIDINE ANTI-RETROVIRAL COMPOSITION | UNIV GEORGIA RES FOUND (US) | 1994-08-24 | — | — | EP | disclosed |
| US-5190926-A | HIV virus | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 1993-03-02 | — | — | US | disclosed |
| US-5159067-A | 5'-Diphosphohexose nucleoside pharmaceutical compositions | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION INC. (US) | 1992-10-27 | — | — | US | disclosed |
| US-5145840-A | Treatment of virac and bacterial infections; aids | BURROUGHS WELLCOME CO. (US) | 1992-09-08 | — | — | US | disclosed |
| US-5118672-A | Microbiocides, viricides, bactericides | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION (US) | 1992-06-02 | — | — | US | disclosed |
| US-5064946-A | 3-azido-2,3-dideoxy-B-D-erythro-pentofuranosyl derivatives of 4(1H)-pyrimidinones; antiretroviral, anti-AIDS | BURROUGHS WELLCOME CO. (US) | 1991-11-12 | — | — | US | disclosed |
| WO-1991000867-A1 | 5'-DIPHOSPHOHEXOSE NUCLEOSIDE PHARMACEUTICAL COMPOSITIONS | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 1991-01-24 | — | — | WO | disclosed |
| EP-0217580-A2 | Therapeutic nucleosides | THE WELLCOME FOUNDATION LIMITED (GB) | 1987-04-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080300216-A1 | Dutpase Inhibitors | DUT, DHODH, POLR2H | DUT 1/4885TYMP 32/4885TYMS 15/4885 |
| US-20100075924-A1 | DUTPASE INHIBITORS | DUT, DHODH, CCNO | DUT 1/4885TYMP 39/4885TYMS 29/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.