Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | HSPH1 | Q92598 | 1/20 | 0.39 |
| ▸ | CCR1 | P32246 | 4/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | GRK5 | P34947 | 1/20 | 0.37 |
| ▸ | CDK8 | P49336 | 1/20 | 0.37 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | MPO | P05164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3576153 | 0.92 | LMNA (0.40) | LMNAHPGDMEN1CYP1A2CYP3A4 | |
| SCHEMBL3576623 | 0.92 | LMNA (0.41) | LMNAHPGDMEN1CYP1A2CYP3A4 | |
| SCHEMBL3576637 | 0.91 | LMNA (0.41) | LMNAHPGDMEN1KMT2ACNR1 | |
| SCHEMBL3577493 | 0.90 | LMNA (0.40) | LMNAHPGDMEN1CYP1A2CYP3A4 | |
| SCHEMBL3569717 | 0.89 | LMNA (0.40) | LMNAHPGDMEN1CYP1A2CYP3A4 | |
| SCHEMBL3578904 | 0.88 | LMNA (0.44) | LMNAHPGDMEN1CYP1A2CYP3A4 | |
| SCHEMBL3577795 | 0.88 | LMNA (0.38) | LMNAHPGDMEN1CYP1A2CYP3A4 | |
| SCHEMBL3574302 | 0.88 | CNR1 (0.42) | ATMCNR1SCN9A | |
| SCHEMBL3584132 | 0.87 | LMNA (0.39) | LMNAHPGDMEN1CYP1A2CYP3A4 | |
| SCHEMBL3583457 | 0.87 | LMNA (0.39) | LMNAHPGDMEN1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678818-B2 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | claimed |
| EP-1984340-B1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |