Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 1/20 | 0.47 |
| ▸ | MMP12 | P39900 | 1/20 | 0.47 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.40 |
| ▸ | CCKAR | P32238 | 3/20 | 0.36 |
| ▸ | CCKBR | P32239 | 3/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 4/20 | 0.35 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | NPC1L1 | Q9UHC9 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3664850 | 0.93 | PRKCA (0.40) | PRKCAMMP12PSEN1PSEN2APH1B | |
| SCHEMBL3630941 | 0.88 | PRKCA (0.49) | PRKCAMMP12PSEN1PSEN2APH1B | |
| SCHEMBL3942843 | 0.82 | PRKCA (0.51) | PRKCAMMP12SCN9ANR1I2EPHX2 | |
| SCHEMBL2960110 | 0.80 | PRKCA (0.63) | PRKCAMMP12SCN9ANR1I2NPC1L1 | |
| SCHEMBL874916 | 0.78 | PRKCA (0.50) | PRKCAMMP12SCN9ANR1I2CCNB2 | |
| SCHEMBL391104 | 0.78 | PRKCA (0.54) | PRKCAMMP12SCN9ANR1I2CYP3A4 | |
| SCHEMBL4107837 | 0.78 | PRKCA (0.43) | PRKCAMMP12SCN9ANR1I2CYP3A4 | |
| SCHEMBL4113065 | 0.78 | PRKCA (0.43) | PRKCAMMP12SCN9ANR1I2CYP3A4 | |
| SCHEMBL13940288 | 0.76 | PRKCA (0.44) | PRKCAMMP12SCN9ANR1I2EPHX2 | |
| SCHEMBL3940946 | 0.75 | PRKCA (0.44) | PRKCAMMP12SCN9ANR1I2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7662809-B2 | Tetracyclic indole derivatives as antiviral agents | ISTITUTO DI RICHERCHE DI BIOLOGIA MOLECOLARE P ANGELETTI SPA (IT) | 2010-02-16 | — | — | US | disclosed |