Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 12/20 | 0.50 |
| ▸ | CCND3 | P30281 | 9/20 | 0.50 |
| ▸ | CCND1 | P24385 | 9/20 | 0.50 |
| ▸ | CCND2 | P30279 | 8/20 | 0.50 |
| ▸ | CDK2 | P24941 | 6/20 | 0.50 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.50 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.50 |
| ▸ | CDK1 | P06493 | 4/20 | 0.50 |
| ▸ | CCNE2 | O96020 | 4/20 | 0.50 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.50 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.50 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.50 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.50 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.50 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.50 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.50 |
| ▸ | AURKA | O14965 | 3/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.49 |
| ▸ | CDK7 | P50613 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3583463 | 0.90 | CDK4 (0.52) | CDK4CCND3CCND1CCND2CDK2 | |
| SCHEMBL3591405 | 0.84 | SYK (0.38) | CDK4CCND3CCND1CCND2CDK2 | |
| SCHEMBL3580939 | 0.83 | CDK4 (0.53) | CDK4CCND3CCND1CCND2CDK2 | |
| SCHEMBL3587865 | 0.81 | AURKA (0.46) | CDK4CCND3CCND1CCND2CDK2 | |
| SCHEMBL3587869 | 0.79 | CDK1 (0.47) | CDK4CCND3CCND1CCND2CDK2 | |
| SCHEMBL1355286 | 0.79 | CDK4 (0.59) | CDK4CCND3CCND1CCND2CDK2 | |
| SCHEMBL344015 | 0.78 | CDK4 (0.66) | CDK4CCND3CCND1CCND2CDK2 | |
| SCHEMBL1355810 | 0.78 | CDK4 (0.60) | CDK4CCND3CCND1CCND2FGFR4 | |
| SCHEMBL3571516 | 0.77 | EGFR (0.56) | CDK4CCND3CCND1CCND2CDK2 | |
| SCHEMBL1355371 | 0.77 | EGFR (0.50) | CDK4CCND3CCND1CCND2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100190787-A1 | Modulators of Mitotic Kinases | BIOGEN IDEC MA INC | 2010-07-29 | — | — | US | claimed |
| US-20100190787-A1 | Modulators of Mitotic Kinases | BIOGEN IDEC MA INC | 2010-07-29 | — | — | US | disclosed |
| EP-2108019-A2 | 1-H-PYRAZOLO[3,4B]PYRIMIDINE DERIVATIVES AND THEIR USE AS MODULATORS OF MITOTIC KINASES | Biogen Idec MA, Inc. (US) | 2009-10-14 | — | — | EP | disclosed |
| WO-2008094575-A2 | 1-H-PYRAZOLO(3,4B)PYRIMIDINE DERIVATIVES AND THEIR USE AS MODULATORS OF MITOTIC KINASES | BIOGEN IDEC MA INC. (US) | 2008-08-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100190787-A1 | Modulators of Mitotic Kinases | CDK1, BUB1, BUB1B | CDK4 102/4885CCND3 256/4885CCND1 210/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.