Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.45 |
| ▸ | PRKAA1 | Q13131 | 5/20 | 0.44 |
| ▸ | PRKAA2 | P54646 | 4/20 | 0.44 |
| ▸ | KDR | P35968 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.42 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4757647 | 0.92 | PRKAA1 (0.40) | TDP1CHEK1PRKAA1PRKAA2KDR | |
| SCHEMBL4756943 | 0.90 | PRKAA1 (0.42) | TDP1CHEK1PRKAA1PRKAA2KDR | |
| SCHEMBL4757832 | 0.88 | PRKAA1 (0.39) | CHEK1PRKAA1PRKAA2KDRPDGFRB | |
| SCHEMBL4756597 | 0.87 | PRKAA1 (0.38) | CHEK1PRKAA1PRKAA2KDRALDH1A1 | |
| SCHEMBL3575353 | 0.86 | ACHE (0.40) | CHEK1PRKAA1PRKAA2KDRACHE | |
| SCHEMBL3582267 | 0.86 | FLT3 (0.45) | CHEK1KDRMEN1KMT2AKCNH2 | |
| SCHEMBL3573599 | 0.85 | IKBKB (0.43) | KDRMEN1KMT2AFGFR1ACHE | |
| SCHEMBL3572841 | 0.83 | NTRK1 (0.40) | NTRK1PDPK1AKT2 | |
| SCHEMBL3575063 | 0.81 | PLAU (0.41) | NTRK1PDPK1AKT2 | |
| SCHEMBL3572820 | 0.81 | AKT2 (0.38) | CHEK1PRKAA1PRKAA2NTRK1CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7692005-B2 | Kinase inhibitors | ALLERGAN, INC. (US) | 2010-04-06 | — | — | US | claimed |
| EP-1902025-A1 | KINASE INHIBITORS | Allergan, Inc. (US) | 2008-03-26 | — | — | EP | claimed |
| US-20070032478-A1 | Kinase Inhibitors | ALLERGAN, INC. | 2007-02-08 | — | — | US | claimed |
| WO-2007008895-A1 | KINASE INHIBITORS | ALLERGAN, INC. (US) | 2007-01-18 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070032478-A1 | Kinase Inhibitors | ABL1, LCK, ERBB2 | TDP1 1059/4885CHEK1 161/4885PRKAA1 406/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.