Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 17/20 | 0.47 |
| ▸ | CCND1 | P24385 | 11/20 | 0.47 |
| ▸ | CDK2 | P24941 | 9/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 8/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 7/20 | 0.47 |
| ▸ | FGFR2 | P21802 | 7/20 | 0.47 |
| ▸ | FGFR4 | P22455 | 7/20 | 0.47 |
| ▸ | FGFR3 | P22607 | 7/20 | 0.47 |
| ▸ | CCND2 | P30279 | 4/20 | 0.47 |
| ▸ | CCND3 | P30281 | 4/20 | 0.47 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.47 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.47 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.47 |
| ▸ | CDK6 | Q00534 | 6/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.46 |
| ▸ | BRD2 | P25440 | 1/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.46 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3582554 | 1.00 | CDK4 (0.47) | CDK4CCND1CDK2CCNA2FGFR1 | |
| SCHEMBL3580392 | 1.00 | CDK4 (0.47) | CDK4CCND1CDK2CCNA2FGFR1 | |
| SCHEMBL3586958 | 0.90 | CDK4 (0.55) | CDK4CCND1CDK2CCNA2FGFR1 | |
| SCHEMBL3584323 | 0.90 | CDK4 (0.55) | CDK4CCND1CDK2CCNA2FGFR1 | |
| SCHEMBL3584319 | 0.90 | CDK4 (0.55) | CDK4CCND1CDK2CCNA2FGFR1 | |
| SCHEMBL3587314 | 0.90 | CDK4 (0.48) | CDK4CCND1CDK2CCNA2FGFR1 | |
| SCHEMBL3582757 | 0.90 | CDK4 (0.48) | CDK4CCND1CDK2CCNA2FGFR1 | |
| SCHEMBL3584285 | 0.90 | CDK4 (0.48) | CDK4CCND1CDK2CCNA2FGFR1 | |
| SCHEMBL3590707 | 0.84 | ABL1 (0.39) | CDK4JAK3FLT3CDK1CCNB1 | |
| SCHEMBL3580556 | 0.84 | ABL1 (0.39) | CDK4JAK3FLT3CDK1CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100190787-A1 | Modulators of Mitotic Kinases | BIOGEN IDEC MA INC | 2010-07-29 | — | — | US | claimed |
| US-20100190787-A1 | Modulators of Mitotic Kinases | BIOGEN IDEC MA INC | 2010-07-29 | — | — | US | disclosed |
| EP-2108019-A2 | 1-H-PYRAZOLO[3,4B]PYRIMIDINE DERIVATIVES AND THEIR USE AS MODULATORS OF MITOTIC KINASES | Biogen Idec MA, Inc. (US) | 2009-10-14 | — | — | EP | disclosed |
| WO-2008094575-A2 | 1-H-PYRAZOLO(3,4B)PYRIMIDINE DERIVATIVES AND THEIR USE AS MODULATORS OF MITOTIC KINASES | BIOGEN IDEC MA INC. (US) | 2008-08-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100190787-A1 | Modulators of Mitotic Kinases | CDK1, BUB1, BUB1B | CDK4 102/4885CCND1 210/4885CDK2 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.