Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.50 |
| ▸ | TTR | P02766 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | RECQL | P46063 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | ALPG | P10696 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 5/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.43 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16955161 | 0.88 | MAPT (0.55) | MAPTTTRALDH1A1RECQLNPC1 | |
| SCHEMBL3584921 | 0.85 | MAPT (0.50) | MAPTALDH1A1RECQLNPC1RAB9A | |
| SCHEMBL27777349 | 0.83 | MAPT (0.48) | MAPTALDH1A1RECQLNPC1RAB9A | |
| SCHEMBL27827480 | 0.82 | MAPT (0.52) | MAPTALDH1A1RECQLNPC1RAB9A | |
| SCHEMBL29750606 | 0.81 | TTR (0.64) | MAPTTTRALDH1A1LMNAMEN1 | |
| SCHEMBL704754 | 0.81 | TTR (0.64) | MAPTTTRALDH1A1LMNAMEN1 | |
| SCHEMBL11953000 | 0.81 | MAPT (0.70) | MAPTTTRALDH1A1NPC1RAB9A | |
| SCHEMBL1342619 | 0.80 | ALDH1A1 (0.57) | MAPTALDH1A1NPC1RAB9ALMNA | |
| SCHEMBL11421914 | 0.80 | CYP19A1 (0.60) | MAPTALDH1A1RECQLNPC1RAB9A | |
| SCHEMBL5968434 | 0.80 | MAPT (0.65) | MAPTTTRALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100144741-A1 | ETHANOLAMINE DERIVATIVES USEFUL AS BACE INHIBITORS | FREDERIKSEN MATHIAS | 2010-06-10 | — | — | US | disclosed |
| CN-101528670-A | 2-hydroxy-1, 3-diaminopropane derivatives | NOVARTIS AG (CH) | 2009-09-09 | — | — | CN | disclosed |
| EP-2094645-A1 | 2-HYDROXY-1,3-DIAMINOPROPANE DERIVATIVES | Novartis AG (CH) | 2009-09-02 | — | — | EP | disclosed |
| WO-2008062044-A1 | 2-HYDROXY-1,3-DIAMINOPROPANE DERIVATIVES | NOVARTIS AG (CH) | 2008-05-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100144741-A1 | ETHANOLAMINE DERIVATIVES USEFUL AS BACE INHIBITORS | BACE1, BACE2, APP | MAPT 28/4885TTR 2191/4885ALDH1A1 447/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.