Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 18/20 | 0.58 |
| ▸ | MAPK9 | P45984 | 16/20 | 0.55 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.39 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.39 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.39 |
| ▸ | CDC7 | O00311 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3581345 | 1.00 | MAPKAPK2 (0.58) | MAPKAPK2MAPK9PARP1AURKAJAK2 | |
| SCHEMBL3577917 | 0.95 | MAPKAPK2 (0.58) | MAPKAPK2MAPK9AURKAJAK2LCK | |
| SCHEMBL3577913 | 0.95 | MAPKAPK2 (0.58) | MAPKAPK2MAPK9AURKAJAK2LCK | |
| SCHEMBL3581017 | 0.93 | MAPKAPK2 (0.60) | MAPKAPK2MAPK9CDC7 | |
| SCHEMBL3581018 | 0.93 | MAPKAPK2 (0.60) | MAPKAPK2MAPK9CDC7 | |
| SCHEMBL3994324 | 0.93 | MAPKAPK2 (0.55) | MAPKAPK2MAPK9AURKAJAK2LCK | |
| SCHEMBL3994321 | 0.93 | MAPKAPK2 (0.55) | MAPKAPK2MAPK9AURKAJAK2LCK | |
| SCHEMBL3586262 | 0.92 | MAPKAPK2 (0.58) | MAPKAPK2MAPK9PARP1AURKAJAK2 | |
| SCHEMBL3586260 | 0.92 | MAPKAPK2 (0.58) | MAPKAPK2MAPK9PARP1AURKAJAK2 | |
| SCHEMBL3574525 | 0.91 | MAPKAPK2 (0.56) | MAPKAPK2MAPK9PARP1AURKAJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100069360-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2010-03-18 | — | — | US | claimed |
| US-20100069360-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2010-03-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100069360-A1 | ORGANIC COMPOUNDS | SLCO1B3, CYP3A7, SLCO1B1 | MAPKAPK2 4563/4885MAPK9 2834/4885PARP1 4005/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.