Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | BRAF | P15056 | 17/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13167782 | 0.86 | PKM (0.53) | PKMBRAF | |
| SCHEMBL3601153 | 0.85 | BRAF (0.57) | PKMBRAF | |
| SCHEMBL3593376 | 0.84 | PKM (0.54) | PKMBRAF | |
| SCHEMBL3592471 | 0.82 | BRAF (0.54) | PKMBRAFALDH1A1 | |
| SCHEMBL3585431 | 0.81 | PKM (0.67) | PKMBRAF | |
| SCHEMBL3596236 | 0.80 | PKM (0.69) | PKMBRAF | |
| SCHEMBL13167773 | 0.78 | PKM (0.65) | PKMBRAF | |
| SCHEMBL3586607 | 0.78 | BRAF (0.63) | PKMBRAF | |
| SCHEMBL3593583 | 0.77 | PKM (0.64) | PKMBRAF | |
| SCHEMBL3594701 | 0.77 | BRAF (0.63) | PKMBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7795249-B2 | Certain pyrazoline derivatives with kinase inhibitory activity | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2010-09-14 | — | — | US | claimed |