Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 3/20 | 0.64 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.64 |
| ▸ | TNK2 | Q07912 | 3/20 | 0.46 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.46 |
| ▸ | RIPK2 | O43353 | 7/20 | 0.46 |
| ▸ | NOD2 | Q9HC29 | 7/20 | 0.46 |
| ▸ | ACVR1 | Q04771 | 6/20 | 0.46 |
| ▸ | ABL1 | P00519 | 2/20 | 0.46 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.45 |
| ▸ | WEE1 | P30291 | 6/20 | 0.43 |
| ▸ | SRC | P12931 | 2/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | PAK4 | O96013 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | FYN | P06241 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3577743 | 0.96 | LCK (0.66) | LCKMAPK14TNK2MAP4K2RIPK2 | |
| SCHEMBL3573486 | 0.91 | LCK (0.63) | LCKMAPK14TNK2MAP4K2RIPK2 | |
| SCHEMBL3579092 | 0.91 | LCK (0.63) | LCKMAPK14TNK2MAP4K2RIPK2 | |
| SCHEMBL3579928 | 0.91 | LCK (0.63) | LCKMAPK14TNK2MAP4K2RIPK2 | |
| SCHEMBL3577142 | 0.90 | LCK (0.64) | LCKMAPK14TNK2MAP4K2RIPK2 | |
| SCHEMBL3568326 | 0.88 | LCK (0.69) | LCKMAPK14TNK2MAP4K2RIPK2 | |
| SCHEMBL3573410 | 0.88 | LCK (0.65) | LCKMAPK14TNK2MAP4K2RIPK2 | |
| SCHEMBL3579857 | 0.87 | LCK (0.64) | LCKMAPK14TNK2MAP4K2RIPK2 | |
| SCHEMBL3572689 | 0.85 | LCK (0.65) | LCKMAPK14TNK2MAP4K2RIPK2 | |
| SCHEMBL3572687 | 0.85 | LCK (0.65) | LCKMAPK14TNK2MAP4K2RIPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1789416-B1 | AMIDE DERIVATIVES OF 3-PHENYL DIHYDROPYRIMIDO[4,5-D]PYRIMIDINONES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | HOFFMANN LA ROCHE (CH) | 2009-03-11 | — | — | EP | claimed |
| US-20070232611-A1 | Amide Derivatives of 3-Phenyl-Dihydropyrimido[4,5-D]Pyrimidinones, Their Manufacture and Use as Pharmaceutical Agents | F. HOFFMANN-LA ROCNE AG (CH) | 2007-10-04 | — | — | US | claimed |
| US-7655651-B2 | Amide derivatives of 3-phenyl-dihydropyrimido[4,5-d]pyrimidinones, their manufacture and use as pharmaceutical agents | HOFFMANN-LA ROCHE INC. (US) | 2010-02-02 | — | — | US | disclosed |
| EP-1789416-B1 | AMIDE DERIVATIVES OF 3-PHENYL DIHYDROPYRIMIDO[4,5-D]PYRIMIDINONES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | HOFFMANN LA ROCHE (CH) | 2009-03-11 | — | — | EP | disclosed |
| US-20070232611-A1 | Amide Derivatives of 3-Phenyl-Dihydropyrimido[4,5-D]Pyrimidinones, Their Manufacture and Use as Pharmaceutical Agents | F. HOFFMANN-LA ROCNE AG (CH) | 2007-10-04 | — | — | US | disclosed |
| EP-1789416-A2 | AMIDE DERIVATIVES OF 3-PHENYL DIHYDROPYRIMIDO[4,5-D]PYRIMIDINONES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F. Hoffmann-la Roche AG (CH) | 2007-05-30 | — | — | EP | disclosed |
| WO-2006024486-A2 | AMIDE DERIVATIVES OF 3-PHENYL DIHYDROPYRIMIDO[4,5-D]PYRIMIDINONES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-03-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070232611-A1 | Amide Derivatives of 3-Phenyl-Dihydropyrimido[4,5-D]Pyrimidinones, Their Manufacture and Use as Pharmaceutical Agents | DPYD, THPO, DHPS | LCK 3660/4885MAPK14 1596/4885TNK2 1671/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.