Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAD52 | P43351 | 7/20 | 0.45 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.41 |
| ▸ | UHRF1 | Q96T88 | 2/20 | 0.41 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.41 |
| ▸ | MERTK | Q12866 | 1/20 | 0.40 |
| ▸ | POLR1A | O95602 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | IKBKB | O14920 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL359347 | 0.97 | RAD52 (0.46) | RAD52AOX1UHRF1SMARCA2POLR1A | |
| SCHEMBL359562 | 0.86 | PARP1 (0.32) | POLR1APARP1KDM4EALDH1A1 | |
| SCHEMBL358397 | 0.83 | RAD52 (0.47) | RAD52AOX1UHRF1SMARCA2POLR1A | |
| SCHEMBL358998 | 0.83 | SCN4A (0.34) | PARP1 | |
| SCHEMBL359540 | 0.82 | RAD52 (0.44) | RAD52AOX1UHRF1SMARCA2POLR1A | |
| SCHEMBL358798 | 0.82 | RAD52 (0.46) | RAD52AOX1UHRF1SMARCA2POLR1A | |
| SCHEMBL12503403 | 0.82 | PARP1 (0.36) | PARP1KDM4EALDH1A1 | |
| SCHEMBL360334 | 0.81 | PARP1 (0.47) | PARP1 | |
| SCHEMBL12503322 | 0.78 | PARP1 (0.39) | PARP1KDM4E | |
| SCHEMBL359495 | 0.78 | PARP1 (0.46) | KCNH2PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012006958-A1 | AMIDS SUBSTITUTED INDAZOLE DERIVATIVEES AS PLOY(ADP-RIBOSE)POLYMERASE INHIBITORS | ZHEJIANG BETA PHARMA INC. (CN) | 2012-01-19 | — | — | WO | disclosed |