Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 15/20 | 0.47 |
| ▸ | PARP2 | Q9UGN5 | 4/20 | 0.42 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.42 |
| ▸ | CD38 | P28907 | 1/20 | 0.41 |
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.39 |
| ▸ | AURKA | O14965 | 3/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | CLK2 | P49760 | 1/20 | 0.39 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL359495 | 0.97 | PARP1 (0.46) | PARP1PARP2PARP3CD38RPS6KB1 | |
| SCHEMBL12503403 | 0.90 | PARP1 (0.36) | PARP1PARP2PARP3RPS6KB1AURKA | |
| SCHEMBL359578 | 0.86 | PARP1 (0.47) | PARP1PARP2PARP3CD38RPS6KB1 | |
| SCHEMBL12503322 | 0.86 | PARP1 (0.39) | PARP1PARP2PARP3RPS6KB1AURKA | |
| SCHEMBL361151 | 0.84 | PARP1 (0.45) | PARP1PARP2PARP3RPS6KB1AURKA | |
| SCHEMBL359562 | 0.84 | PARP1 (0.32) | PARP1CD38 | |
| SCHEMBL358329 | 0.83 | PARP1 (0.46) | PARP1PARP2PARP3RPS6KB1AURKA | |
| SCHEMBL358843 | 0.81 | PARP1 (0.44) | PARP1PARP2PARP3RPS6KB1AURKA | |
| SCHEMBL358368 | 0.81 | RAD52 (0.45) | PARP1 | |
| SCHEMBL358998 | 0.81 | SCN4A (0.34) | PARP1PARP2PARP3RPS6KB1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012006958-A1 | AMIDS SUBSTITUTED INDAZOLE DERIVATIVEES AS PLOY(ADP-RIBOSE)POLYMERASE INHIBITORS | ZHEJIANG BETA PHARMA INC. (CN) | 2012-01-19 | — | — | WO | claimed |
| WO-2012006958-A1 | AMIDS SUBSTITUTED INDAZOLE DERIVATIVEES AS PLOY(ADP-RIBOSE)POLYMERASE INHIBITORS | ZHEJIANG BETA PHARMA INC. (CN) | 2012-01-19 | — | — | WO | disclosed |
| WO-2012006958-A1 | AMIDS SUBSTITUTED INDAZOLE DERIVATIVEES AS PLOY(ADP-RIBOSE)POLYMERASE INHIBITORS | ZHEJIANG BETA PHARMA INC. (CN) | 2012-01-19 | — | — | WO | disclosed |