Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 2/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.38 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.38 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.38 |
| ▸ | KDM5A | P29375 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.37 |
| ▸ | SLC6A9 | P48067 | 4/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | RAF1 | P04049 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.36 |
| ▸ | CTSA | P10619 | 1/20 | 0.35 |
| ▸ | HTR5A | P47898 | 1/20 | 0.35 |
| ▸ | CETP | P11597 | 1/20 | 0.35 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3583406 | 0.91 | CNR1 (0.41) | PTGER4CNR1LPAR1LPAR5KDM5A | |
| SCHEMBL3582130 | 0.90 | CNR1 (0.40) | PTGER4CNR1TRPM8LPAR1LPAR5 | |
| SCHEMBL3582301 | 0.88 | NAMPT (0.40) | PTGER4CNR1TRPM8ATMSLC2A1 | |
| SCHEMBL3576340 | 0.86 | CNR1 (0.42) | PTGER4CNR1TRPM8LPAR1LPAR5 | |
| SCHEMBL3577569 | 0.84 | C5AR1 (0.42) | PTGER4LPAR1LPAR5CYP3A4 | |
| SCHEMBL3573512 | 0.83 | HDAC1 (0.36) | KCNH2SLC2A1CYP3A4 | |
| SCHEMBL3571746 | 0.82 | SLC2A1 (0.41) | CNR1LPAR1LPAR5SLC2A1HTR5A | |
| SCHEMBL3570789 | 0.81 | CNR1 (0.39) | CNR1ATMSLC2A1CYP3A4CYP2D6 | |
| SCHEMBL3575233 | 0.81 | SLC2A1 (0.42) | CNR1LPAR1LPAR5ATMALDH1A1 | |
| SCHEMBL3570653 | 0.79 | CNR1 (0.39) | CNR1TRPM8ATMSLC2A1CETP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678818-B2 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | claimed |
| EP-1984340-B1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |