Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 8/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA4 | P22748 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.35 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3573512 | 0.91 | HDAC1 (0.36) | C5AR1HDAC1HDAC6CYP3A4HSP90AA1 | |
| SCHEMBL3582301 | 0.86 | NAMPT (0.40) | HDAC1MEN1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL3583638 | 0.85 | C5AR1 (0.41) | C5AR1MEN1KMT2AF10CHRNA7 | |
| SCHEMBL3569329 | 0.85 | C5AR1 (0.41) | C5AR1MEN1KMT2AF10CHRNA7 | |
| SCHEMBL3576589 | 0.85 | CHRNA7 (0.40) | C5AR1MEN1KMT2ASMN1; SMN2F10 | |
| SCHEMBL3581889 | 0.85 | C5AR1 (0.40) | C5AR1MEN1KMT2AF10CHRNA7 | |
| SCHEMBL3584052 | 0.84 | PTGER4 (0.43) | CYP3A4LPAR1LPAR5PTGER4 | |
| SCHEMBL3584209 | 0.83 | C5AR1 (0.45) | C5AR1HDAC1HDAC6MEN1KMT2A | |
| SCHEMBL3579477 | 0.80 | MCHR1 (0.37) | C5AR1MEN1KMT2AF10CHRNA7 | |
| SCHEMBL3574217 | 0.79 | MCHR1 (0.37) | C5AR1MEN1KMT2AF10CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678818-B2 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | claimed |
| EP-1984340-B1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |