Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 19/20 | 0.58 |
| ▸ | MAPK9 | P45984 | 13/20 | 0.52 |
| ▸ | CDC7 | O00311 | 2/20 | 0.50 |
| ▸ | PLK4 | O00444 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | IKBKB | O14920 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | CHUK | O15111 | 1/20 | 0.44 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.44 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.44 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | PRKCG | P05129 | 1/20 | 0.44 |
| ▸ | INSR | P06213 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3584685 | 1.00 | MAPKAPK2 (0.58) | MAPKAPK2MAPK9CDC7PLK4CHEK1 | |
| SCHEMBL3580940 | 0.88 | MAPKAPK2 (0.60) | MAPKAPK2MAPK9CDC7PLK4CHEK1 | |
| SCHEMBL3580941 | 0.88 | MAPKAPK2 (0.60) | MAPKAPK2MAPK9CDC7PLK4CHEK1 | |
| SCHEMBL3574365 | 0.84 | MAPKAPK2 (0.54) | MAPKAPK2MAPK9CDC7 | |
| SCHEMBL3574369 | 0.84 | MAPKAPK2 (0.54) | MAPKAPK2MAPK9CDC7 | |
| SCHEMBL3584239 | 0.83 | MAPKAPK2 (0.57) | MAPKAPK2MAPK9CDC7KDR | |
| SCHEMBL3584241 | 0.83 | MAPKAPK2 (0.57) | MAPKAPK2MAPK9CDC7KDR | |
| SCHEMBL3586262 | 0.82 | MAPKAPK2 (0.58) | MAPKAPK2MAPK9CDC7AURKAJAK2 | |
| SCHEMBL3586260 | 0.82 | MAPKAPK2 (0.58) | MAPKAPK2MAPK9CDC7AURKAJAK2 | |
| SCHEMBL3581345 | 0.82 | MAPKAPK2 (0.58) | MAPKAPK2MAPK9CDC7AURKAJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100069360-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2010-03-18 | — | — | US | claimed |
| US-20100069360-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2010-03-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100069360-A1 | ORGANIC COMPOUNDS | SLCO1B3, CYP3A7, SLCO1B1 | MAPKAPK2 4563/4885MAPK9 2834/4885CDC7 3142/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.