Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 2/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.35 |
| ▸ | CCR5 | P51681 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3586837 | 1.00 | AKR1C3 (0.36) | AKR1C3AKR1C2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3585512 | 1.00 | AKR1C3 (0.36) | AKR1C3AKR1C2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3586832 | 1.00 | AKR1C3 (0.36) | AKR1C3AKR1C2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3602359 | 0.96 | AKR1C3 (0.37) | AKR1C3AKR1C2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3602364 | 0.96 | AKR1C3 (0.37) | AKR1C3AKR1C2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3585737 | 0.94 | AKR1C3 (0.37) | AKR1C3AKR1C2CCR5TACR1MAPK1 | |
| SCHEMBL3585732 | 0.94 | AKR1C3 (0.37) | AKR1C3AKR1C2CCR5TACR1MAPK1 | |
| SCHEMBL3599457 | 0.92 | AKR1C3 (0.36) | AKR1C3AKR1C2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3599460 | 0.92 | AKR1C3 (0.36) | AKR1C3AKR1C2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3600419 | 0.91 | AKR1C3 (0.37) | AKR1C3AKR1C2SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100190768-A1 | NOVEL FUSED PYROLE DERIVATIVE | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2010-07-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100190768-A1 | NOVEL FUSED PYROLE DERIVATIVE | NR3C1, NR3C2, NR0B1 | AKR1C3 278/4885AKR1C2 614/4885SLC6A2 4559/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.