Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 1/20 | 0.48 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | DYRK3 | O43781 | 5/20 | 0.47 |
| ▸ | CLK1 | P49759 | 5/20 | 0.47 |
| ▸ | CLK2 | P49760 | 5/20 | 0.47 |
| ▸ | CLK3 | P49761 | 5/20 | 0.47 |
| ▸ | GSK3B | P49841 | 5/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.47 |
| ▸ | DYRK2 | Q92630 | 5/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.47 |
| ▸ | DYRK4 | Q9NR20 | 5/20 | 0.47 |
| ▸ | DYRK1B | Q9Y463 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL418266 | 0.84 | NPC1 (0.55) | NTRK1NTRK2NPC1RAB9AKDM4E | |
| SCHEMBL27910402 | 0.82 | NPC1 (0.50) | NTRK1NTRK2NPC1RAB9AKDM4E | |
| SCHEMBL12600125 | 0.77 | RAB9A (0.47) | NTRK1NTRK2NPC1RAB9AKDM4E | |
| SCHEMBL4713744 | 0.77 | NPC1 (0.49) | NTRK1NTRK2NPC1RAB9AKDM4E | |
| SCHEMBL277372 | 0.76 | NPC1 (0.50) | NTRK1NTRK2NPC1RAB9AKDM4E | |
| SCHEMBL19926163 | 0.76 | OGA (0.47) | NPC1RAB9AKDM4EMEN1KMT2A | |
| SCHEMBL24347730 | 0.73 | NPC1 (0.45) | NTRK1NTRK2NPC1RAB9AKDM4E | |
| SCHEMBL21123817 | 0.73 | NPC1 (0.45) | NTRK1NTRK2NPC1RAB9AKDM4E | |
| SCHEMBL2175917 | 0.73 | DYRK1A (0.46) | NTRK1NTRK2NPC1RAB9AKDM4E | |
| SCHEMBL17541595 | 0.73 | NPC1 (0.45) | NTRK1NTRK2NPC1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2081937-B1 | TRIAZOLOPYRIDAZINE PROTEIN KINASE MODULATORS | SGX PHARMACEUTICALS INC (US) | 2012-09-12 | — | — | EP | disclosed |
| US-8071581-B2 | Triazolopyridazine protein kinase modulators | SGX PHARMACEUTICALS, INC. (US) | 2011-12-06 | — | — | US | disclosed |
| US-20100120739-A1 | TRIAZOLOPYRIDAZINE PROTEIN KINASE MODULATORS | SGX PHARMACEUTICALS, INC. | 2010-05-13 | — | — | US | disclosed |
| EP-2081937-A2 | TRIAZOLOPYRIDAZINE PROTEIN KINASE MODULATORS | SGX Pharmaceuticals, Inc. (US) | 2009-07-29 | — | — | EP | disclosed |
| WO-2008051805-A2 | TRIAZOLO-PYRIDAZINE PROTEIN KINASE MODULATORS | SGX PHARMACEUTICALS, INC. (US) | 2008-05-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100120739-A1 | TRIAZOLOPYRIDAZINE PROTEIN KINASE MODULATORS | MAP4K5, MAPKAPK5, MAP4K2 | NTRK1 1131/4885NTRK2 1742/4885NPC1 2777/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.