Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.45 |
| ▸ | CA2 | P00918 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13163361 | 0.92 | TSHR (0.53) | TSHRALDH1A1HSD17B10KDM4ECA1 | |
| SCHEMBL16752384 | 0.90 | TSHR (0.65) | TSHRALDH1A1HSD17B10KDM4ECA1 | |
| SCHEMBL15019745 | 0.87 | TSHR (0.61) | TSHRALDH1A1HSD17B10KDM4ECA1 | |
| SCHEMBL28566543 | 0.85 | TSHR (0.59) | TSHRALDH1A1HSD17B10KDM4ECA1 | |
| SCHEMBL1790478 | 0.85 | TSHR (0.59) | TSHRALDH1A1HSD17B10KDM4ECA1 | |
| SCHEMBL32662611 | 0.84 | TSHR (0.46) | TSHRALDH1A1HSD17B10KDM4EPOLB | |
| SCHEMBL27264997 | 0.84 | TSHR (0.46) | TSHRALDH1A1HSD17B10KDM4EPOLB | |
| SCHEMBL3676421 | 0.83 | TSHR (0.56) | TSHRALDH1A1HSD17B10CA1CA2 | |
| SCHEMBL5386421 | 0.82 | TSHR (0.62) | TSHRALDH1A1HSD17B10KDM4ECA1 | |
| SCHEMBL8727691 | 0.81 | TSHR (0.53) | TSHRALDH1A1HSD17B10KDM4ECA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100075986-A1 | Oxophenyl-Cyclohexyl-Propanolamine Derivatives, Production And Use Thereof In Therapeutics | SANOFI-AVENTIS (FR) | 2010-03-25 | — | — | US | disclosed |
| US-7625929-B2 | Oxophenyl-cyclohexyl-propanolamine derivatives, production and use thereof in therapeutics | SANOFI-AVENTIS (FR) | 2009-12-01 | — | — | US | disclosed |
| US-7453010-B2 | Phenylcyclohexylpropanolamine derivatives, preparation and therapeutic application thereof | SANOFI AVENTIS (FR) | 2008-11-18 | — | — | US | disclosed |
| US-20060100283-A1 | Phenylcyclohexylpropanolamine derivatives, preparation and therapeutic application thereof | SANOFI-AVENTIS (FR) | 2006-05-11 | — | — | US | disclosed |
| US-20050176731-A1 | Oxophenyl-cyclohexyl-propanolamine derivatives, production and use therof in therapeutics | SANOFI-AVENTIS (FR) | 2005-08-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060100283-A1 | Phenylcyclohexylpropanolamine derivatives, preparation and therapeutic application thereof | CHRM1, CHRM2, C1R | TSHR 177/4885ALDH1A1 1769/4885HSD17B10 562/4885 |
| US-20100075986-A1 | Oxophenyl-Cyclohexyl-Propanolamine Derivatives, Production And Use Thereof In Therapeutics | HRH4, HRH3, AOC3 | TSHR 317/4885ALDH1A1 2106/4885HSD17B10 1720/4885 |
| US-20050176731-A1 | Oxophenyl-cyclohexyl-propanolamine derivatives, production and use therof in therapeutics | HRH4, HRH3, HTR3C | TSHR 317/4885ALDH1A1 2731/4885HSD17B10 2600/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.