Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 14/20 | 0.53 |
| ▸ | CDK1 | P06493 | 14/20 | 0.53 |
| ▸ | CCNB1 | P14635 | 14/20 | 0.53 |
| ▸ | MARK3 | P27448 | 2/20 | 0.47 |
| ▸ | MARK4 | Q96L34 | 2/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3576674 | 1.00 | AURKA (0.53) | AURKACDK1CCNB1MARK3MARK4 | |
| SCHEMBL3576677 | 1.00 | AURKA (0.53) | AURKACDK1CCNB1MARK3MARK4 | |
| SCHEMBL3585045 | 0.88 | AURKA (0.54) | AURKACDK1CCNB1MARK3MARK4 | |
| SCHEMBL3588626 | 0.88 | AURKA (0.54) | AURKACDK1CCNB1MARK3MARK4 | |
| SCHEMBL3585042 | 0.88 | AURKA (0.54) | AURKACDK1CCNB1MARK3MARK4 | |
| SCHEMBL1355699 | 0.87 | AURKA (0.45) | AURKACDK1CCNB1MARK3MARK4 | |
| SCHEMBL1355702 | 0.87 | AURKA (0.45) | AURKACDK1CCNB1MARK3MARK4 | |
| SCHEMBL1355460 | 0.85 | MARK3 (0.52) | AURKACDK1CCNB1MARK3MARK4 | |
| SCHEMBL3585565 | 0.85 | MARK3 (0.42) | AURKACDK1CCNB1MARK3MARK4 | |
| SCHEMBL3576056 | 0.85 | MARK3 (0.42) | AURKACDK1CCNB1MARK3MARK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100190787-A1 | Modulators of Mitotic Kinases | BIOGEN IDEC MA INC | 2010-07-29 | — | — | US | claimed |
| US-20100190787-A1 | Modulators of Mitotic Kinases | BIOGEN IDEC MA INC | 2010-07-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100190787-A1 | Modulators of Mitotic Kinases | CDK1, BUB1, BUB1B | AURKA 10/4885CDK1 1/4885CCNB1 17/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.