Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.53 |
| ▸ | MAPT | P10636 | 9/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3590274 | 0.91 | MAPT (0.54) | ALDH1A1MAPTKMT2AMEN1RXFP1 | |
| SCHEMBL4117405 | 0.90 | MAPT (0.55) | ALDH1A1MAPTKMT2AMEN1RXFP1 | |
| SCHEMBL3227136 | 0.81 | MAPT (0.72) | ALDH1A1MAPTKMT2AMEN1RXFP1 | |
| SCHEMBL3599399 | 0.80 | MAPT (0.55) | ALDH1A1MAPTKMT2AMEN1RXFP1 | |
| SCHEMBL3587530 | 0.80 | MAPT (0.55) | ALDH1A1MAPTKMT2AMEN1RXFP1 | |
| SCHEMBL4105396 | 0.79 | MAPT (0.58) | ALDH1A1MAPTKMT2AMEN1RXFP1 | |
| SCHEMBL22115166 | 0.78 | MAPT (0.56) | ALDH1A1MAPTKMT2AMEN1RXFP1 | |
| SCHEMBL3589979 | 0.78 | MAPT (0.53) | ALDH1A1MAPTKMT2AMEN1RXFP1 | |
| SCHEMBL3939838 | 0.78 | MAPT (0.53) | ALDH1A1MAPTKMT2AMEN1RXFP1 | |
| SCHEMBL3326985 | 0.77 | MAPT (0.55) | ALDH1A1MAPTKMT2AMEN1RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100069350-A1 | New Pyridine Analogues III | ASTRAZENECA AB (SE) | 2010-03-18 | — | — | US | disclosed |
| US-20080039437-A1 | New Pyridine Analogues III | ASTRAZENECA AB (SE) | 2008-02-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080039437-A1 | New Pyridine Analogues III | P2RY12, P2RY1, P2RY11 | ALDH1A1 1928/4885MAPT 4340/4885KMT2A 4378/4885 |
| US-20100069350-A1 | New Pyridine Analogues III | P2RY12, P2RY11, P2RY1 | ALDH1A1 1691/4885MAPT 3664/4885KMT2A 4683/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.