Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 15/20 | 0.76 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.74 |
| ▸ | PIM1 | P11309 | 2/20 | 0.74 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.74 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.74 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.74 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.74 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.74 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.74 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.74 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.74 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.74 |
| ▸ | BRSK1 | Q8TDC3 | 1/20 | 0.74 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.74 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.74 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.60 |
| ▸ | LCK | P06239 | 1/20 | 0.60 |
| ▸ | CSF1R | P07333 | 1/20 | 0.60 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.60 |
| ▸ | MARK3 | P27448 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6584505 | 0.88 | MAP4K4 (0.57) | PARP1MAP4K4PIM1PIM3AURKB | |
| SCHEMBL3577816 | 0.85 | MAP4K4 (1.00) | PARP1MAP4K4PIM1PIM3AURKB | |
| SCHEMBL3586495 | 0.85 | ADORA2A (0.56) | PARP1MAP4K4PIM1PIM3AURKB | |
| SCHEMBL3582877 | 0.82 | PARP1 (0.69) | PARP1MAP4K4PIM1PIM3AURKB | |
| SCHEMBL6805372 | 0.79 | PKN2 (0.63) | PARP1MAP4K4PIM1PIM3AURKB | |
| SCHEMBL7137094 | 0.78 | PARP1 (0.80) | PARP1MAP4K4PIM1PIM3AURKB | |
| SCHEMBL7131923 | 0.77 | PARP1 (0.79) | PARP1MAP4K4PIM1PIM3AURKB | |
| SCHEMBL7134204 | 0.76 | PARP1 (0.67) | PARP1MAP4K4PIM1PIM3AURKB | |
| SCHEMBL5450300 | 0.76 | PARP1 (0.69) | PARP1PKN2PKN1PLA2G2AALOX15 | |
| SCHEMBL4321727 | 0.76 | PARP1 (1.00) | PARP1MAP4K4PIM1PIM3AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7781596-B1 | Substituted 2-phenylbenzimidazoles, the production thereof and their use | ABBOTT LABORATORIES (US) | 2010-08-24 | — | — | US | disclosed |
| US-7781596-B1 | Substituted 2-phenylbenzimidazoles, the production thereof and their use | ABBOTT LABORATORIES (US) | 2010-08-24 | — | — | US | disclosed |