Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MARK3 | P27448 | 2/20 | 0.42 |
| ▸ | MARK4 | Q96L34 | 2/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 8/20 | 0.41 |
| ▸ | CDK1 | P06493 | 7/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 6/20 | 0.41 |
| ▸ | ULK1 | O75385 | 1/20 | 0.40 |
| ▸ | ULK2 | Q8IYT8 | 1/20 | 0.40 |
| ▸ | CDK4 | P11802 | 5/20 | 0.39 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | CCND1 | P24385 | 3/20 | 0.38 |
| ▸ | CCND2 | P30279 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3576056 | 1.00 | MARK3 (0.42) | MARK3MARK4PIK3CDPIK3R1SYK | |
| SCHEMBL3585565 | 1.00 | MARK3 (0.42) | MARK3MARK4PIK3CDPIK3R1SYK | |
| SCHEMBL1355871 | 0.87 | SYK (0.43) | MARK3MARK4PIK3CDPIK3R1SYK | |
| SCHEMBL1355869 | 0.87 | SYK (0.43) | MARK3MARK4PIK3CDPIK3R1SYK | |
| SCHEMBL3583888 | 0.86 | GSK3B (0.47) | MARK3MARK4AURKAAURKB | |
| SCHEMBL3588604 | 0.86 | GSK3B (0.47) | MARK3MARK4AURKAAURKB | |
| SCHEMBL3583884 | 0.86 | GSK3B (0.47) | MARK3MARK4AURKAAURKB | |
| SCHEMBL1353830 | 0.85 | MARK3 (0.40) | MARK3MARK4PIK3CDPIK3R1AURKA | |
| SCHEMBL1353835 | 0.85 | MARK3 (0.40) | MARK3MARK4PIK3CDPIK3R1AURKA | |
| SCHEMBL3587815 | 0.85 | MARK3 (0.42) | MARK3MARK4PIK3CDPIK3R1SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100190787-A1 | Modulators of Mitotic Kinases | BIOGEN IDEC MA INC | 2010-07-29 | — | — | US | claimed |
| US-20100190787-A1 | Modulators of Mitotic Kinases | BIOGEN IDEC MA INC | 2010-07-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100190787-A1 | Modulators of Mitotic Kinases | CDK1, BUB1, BUB1B | MARK3 149/4885MARK4 181/4885PIK3CD 347/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.