⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11772668 | 0.80 | — | — | |
| SCHEMBL58748 | 0.76 | GRM4 (0.45) | — | |
| SCHEMBL20327 | 0.72 | — | — | |
| SCHEMBL108849 | 0.71 | — | — | |
| SCHEMBL358618 | 0.71 | — | — | |
| SCHEMBL2693553 | 0.69 | — | — | |
| SCHEMBL5984121 | 0.69 | — | — | |
| SCHEMBL5443031 | 0.69 | GRM4 (0.41) | — | |
| SCHEMBL14420440 | 0.69 | GRM4 (0.41) | — | |
| SCHEMBL18748 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 172 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8026243-B2 | [4,5′]Bipyrimidinyl-6,4′-diamine derivatives as protein kinase inhibitors | NOVARTIS AG (CH) | 2011-09-27 | — | — | US | claimed |
| EP-2044036-B1 | [4,5']BIPYRIMIDINYL-6,4'-DIAMINE DERIVATIVES AS PROTEIN KINASE INHBITORS | IRM LLC (BM) | 2011-05-04 | — | — | EP | claimed |
| US-20110092491-A1 | Compounds and Compositions as Inhibitors of Receptor Tyrosine Kinase Activity | NOVARTIS AG (CH) | 2011-04-21 | — | — | US | claimed |
| US-20100234376-A1 | [4,5']Bipyrimidinyl-6,4'-Diamine Deriviatives as Protein Kinase Inhibitors | NOVARTIS AG | 2010-09-16 | — | — | US | claimed |
| EP-2207852-A1 | SILICONE HYDROGELS WITH AMINO SURFACE GROUPS | Bausch & Lomb Incorporated (US) | 2010-07-21 | — | — | EP | claimed |
| US-20100056494-A1 | PURINE COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS FOR THE TREATMENT OF PLASMODIUM RELATED DISEASES | IRM LLC (BM) | 2010-03-04 | — | — | US | claimed |
| CN-101622001-A | Purine compounds and compositions as kinase inhibitors for the treatment of plasmodium related diseases | IRM LLC | 2010-01-06 | — | — | CN | claimed |
| EP-2124954-A2 | PURINE COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS FOR THE TREATMENT OF PLASMODIUM RELATED DISEASES | IRM LLC (BM) | 2009-12-02 | — | — | EP | claimed |
| CN-101511798-A | [4, 5 '] bipyrimidinyl-6, 4' -diamine derivatives as protein kinase inhibitors | IRM LLC (VG) | 2009-08-19 | — | — | CN | claimed |
| WO-2009055226-A1 | SILICONE HYDROGELS WITH AMINO SURFACE GROUPS | BAUSCH & LOMB INCORPORATED (US) | 2009-04-30 | — | — | WO | claimed |
| WO-2008094737-A2 | PURINE COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS FOR THE TREATMENT OF PLASMODIUM RELATED DISEASES | IRM LLC (BM) | 2008-08-07 | — | — | WO | claimed |
| WO-2008008747-A1 | [4,5']BIPYRIMIDINYL-6,4'-DIAMINE DERIVATIVES AS PROTEIN KINASE INHBITORS | IRM LLC (BM) | 2008-01-17 | — | — | WO | claimed |
| CN-1835952-A | 6-substituted anilinopurine as RTK inhibitors | IRM LLC (BM) | 2006-09-20 | — | — | CN | claimed |
| EP-1656378-A2 | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF RECEPTOR TYROSINE KINASE ACTIVITY | IRM LLC (BM) | 2006-05-17 | — | — | EP | claimed |
| US-20050124637-A1 | Compounds and compositions as inhibitors of receptor tyrosine kinase activity | IRM LLC (BM) | 2005-06-09 | — | — | US | claimed |
| WO-2005016528-A2 | 6-SUBSTITUTED ANILINO PURINES AS RTK INHIBITORS | IRM LLC (BM) | 2005-02-24 | — | — | WO | claimed |
| EP-0517843-A1 | POLYUREA GEL COMPOSITIONS AND ARTICLES THEREFROM | RAYCHEM CORPORATION (US) | 1992-12-16 | — | — | EP | claimed |
| US-5104930-A | Sealing and protecting substrates; tensile strength, elongation, toughness, compatibility | RAYCHEM CORPORATION (US) | 1992-04-14 | — | — | US | claimed |
| WO-1991013109-A1 | POLYUREA GEL COMPOSITIONS AND ARTICLES THEREFROM | RAYCHEM CORPORATION (US) | 1991-09-05 | — | — | WO | claimed |
| US-4720548-A | Quinoxaline adducts useful as anthelmintics | ANGUS CHEMICAL COMPANY (US) | 1988-01-19 | — | — | US | claimed |