Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 3/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | AKT1 | P31749 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ATR | Q13535 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3595762 | 0.84 | CYP2D6 (0.47) | PIK3CAPIK3CBPIK3CGPDE10ACYP2D6 | |
| SCHEMBL3614240 | 0.77 | ATR (0.60) | PIK3CAPIK3CBPIK3CGATRMTOR | |
| SCHEMBL3588014 | 0.75 | PIK3CA (0.51) | PIK3CAPIK3CBCYP2D6CYP1A2MAPT | |
| SCHEMBL3607289 | 0.75 | PIK3CB (0.39) | PIK3CAPIK3CBPIK3CGPDE10ACYP2D6 | |
| SCHEMBL3607291 | 0.74 | CHRNB2 (0.44) | PIK3CAPIK3CBALDH1A1KDM4ELMNA | |
| SCHEMBL17859942 | 0.71 | CYP1A2 (0.54) | PIK3CBCYP2D6CYP1A2MAPTPOLB | |
| SCHEMBL2493395 | 0.70 | CYP1A2 (0.49) | PIK3CBCYP2D6CYP1A2MAPTPOLB | |
| SCHEMBL3938069 | 0.70 | CYP1A2 (0.49) | PIK3CAPIK3CBCYP2D6CYP1A2MAPT | |
| SCHEMBL3554877 | 0.70 | PIK3CB (0.57) | PIK3CAPIK3CBCYP2D6CYP1A2HTT | |
| SCHEMBL3592537 | 0.70 | PIK3CB (0.46) | PIK3CAPIK3CBAKT1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100256143-A1 | PHARMACEUTICAL COMPOUNDS | BAKER STEWART JAMES | 2010-10-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100256143-A1 | PHARMACEUTICAL COMPOUNDS | PIK3CA, PIK3CD, JAK2 | PIK3CA 1/4885PIK3CB 9/4885PIK3CG 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.