Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 12/20 | 0.43 |
| ▸ | GSK3A | P49840 | 10/20 | 0.43 |
| ▸ | AURKA | O14965 | 10/20 | 0.43 |
| ▸ | JAK2 | O60674 | 2/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3588605 | 1.00 | GSK3B (0.43) | GSK3BGSK3AAURKAJAK2AURKB | |
| SCHEMBL3588602 | 1.00 | GSK3B (0.43) | GSK3BGSK3AAURKAJAK2AURKB | |
| SCHEMBL3580556 | 0.86 | ABL1 (0.39) | AURKAAURKB | |
| SCHEMBL3592265 | 0.86 | ABL1 (0.39) | AURKAAURKB | |
| SCHEMBL3590707 | 0.86 | ABL1 (0.39) | AURKAAURKB | |
| SCHEMBL3592469 | 0.84 | GRM5 (0.40) | GSK3BAURKAJAK2 | |
| SCHEMBL3583888 | 0.83 | GSK3B (0.47) | GSK3BGSK3AAURKAJAK2AURKB | |
| SCHEMBL3588604 | 0.83 | GSK3B (0.47) | GSK3BGSK3AAURKAJAK2AURKB | |
| SCHEMBL3583884 | 0.83 | GSK3B (0.47) | GSK3BGSK3AAURKAJAK2AURKB | |
| SCHEMBL3587167 | 0.82 | AURKA (0.51) | AURKAJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100190787-A1 | Modulators of Mitotic Kinases | BIOGEN IDEC MA INC | 2010-07-29 | — | — | US | claimed |
| US-20100190787-A1 | Modulators of Mitotic Kinases | BIOGEN IDEC MA INC | 2010-07-29 | — | — | US | disclosed |
| EP-2108019-A2 | 1-H-PYRAZOLO[3,4B]PYRIMIDINE DERIVATIVES AND THEIR USE AS MODULATORS OF MITOTIC KINASES | Biogen Idec MA, Inc. (US) | 2009-10-14 | — | — | EP | disclosed |
| WO-2008094575-A2 | 1-H-PYRAZOLO(3,4B)PYRIMIDINE DERIVATIVES AND THEIR USE AS MODULATORS OF MITOTIC KINASES | BIOGEN IDEC MA INC. (US) | 2008-08-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100190787-A1 | Modulators of Mitotic Kinases | CDK1, BUB1, BUB1B | GSK3B 116/4885GSK3A 129/4885AURKA 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.