Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 13/20 | 0.64 |
| ▸ | KDR | P35968 | 12/20 | 0.64 |
| ▸ | HCK | P08631 | 11/20 | 0.64 |
| ▸ | SRC | P12931 | 11/20 | 0.64 |
| ▸ | FYN | P06241 | 2/20 | 0.48 |
| ▸ | RET | P07949 | 3/20 | 0.47 |
| ▸ | ABL1 | P00519 | 2/20 | 0.47 |
| ▸ | KIT | P10721 | 2/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.47 |
| ▸ | TEK | Q02763 | 1/20 | 0.47 |
| ▸ | KIF5B | P33176 | 2/20 | 0.42 |
| ▸ | ETV6 | P41212 | 2/20 | 0.42 |
| ▸ | CCDC6 | Q16204 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | NPM1 | P06748 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3594846 | 0.90 | LCK (0.66) | LCKKDRHCKSRCFYN | |
| Bromide SCHEMBL3595648 | 0.89 | LCK (0.64) | LCKKDRHCKSRCFYN | |
| SCHEMBL3587748 | 0.87 | LCK (0.62) | LCKKDRHCKSRCFYN | |
| SCHEMBL3587624 | 0.87 | LCK (0.51) | LCKKDRHCKSRCRET | |
| SCHEMBL3589781 | 0.83 | LCK (0.57) | LCKKDRHCKSRCFYN | |
| SCHEMBL4171013 | 0.79 | LCK (1.00) | LCKKDRHCKSRCFYN | |
| SCHEMBL3593875 | 0.77 | KMT2A (0.61) | LCKKDRHCKSRCRET | |
| Hydrochloric Acid SCHEMBL3585873 | 0.76 | KMT2A (0.60) | LCKKDRHCKSRCRET | |
| SCHEMBL4184434 | 0.76 | NPC1 (0.72) | LCKKDRHCKSRCRET | |
| SCHEMBL4178000 | 0.75 | MEN1 (0.75) | LCKKDRHCKSRCRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100029636-A1 | Lck inhibitors | NOVARTIS AG (CH) | 2010-02-04 | — | — | US | disclosed |
| US-20100029636-A1 | Lck inhibitors | NOVARTIS AG (CH) | 2010-02-04 | — | — | US | disclosed |
| EP-2074127-A1 | PYRAZOLO [1, 5-A]PYRIMIDINE DERIVATIVES AND THEIR THERAPEUTIC USE | Novartis AG (CH) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008037459-A1 | PYRAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES AND THEIR THERAPEUTIC USE | NOVARTIS AG (CH) | 2008-04-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029636-A1 | Lck inhibitors | LCK, ZAP70, FYN | LCK 1/4885KDR 1630/4885HCK 42/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.