Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 7/20 | 0.49 |
| ▸ | SYK | P43405 | 3/20 | 0.42 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.37 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.37 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.36 |
| ▸ | JUN | P05412 | 5/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.35 |
| ▸ | GSK3A | P49840 | 2/20 | 0.35 |
| ▸ | GSK3B | P49841 | 2/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | CCND1 | P24385 | 1/20 | 0.34 |
| ▸ | CCND2 | P30279 | 1/20 | 0.34 |
| ▸ | CCND3 | P30281 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3583178 | 0.82 | SRC (0.42) | SYKEIF2AK4PDGFRAGSK3AGSK3B | |
| SCHEMBL3585927 | 0.80 | STAT6 (0.53) | SYKPDGFRACDK4CCND1CCND2 | |
| SCHEMBL3571516 | 0.79 | EGFR (0.56) | PDGFRACDK4CCND1CCND2CCND3 | |
| SCHEMBL3588808 | 0.79 | CDK4 (0.54) | CDK4CCND1CCND2CCND3STAT6 | |
| SCHEMBL3589735 | 0.78 | GSK3B (0.53) | GSK3AGSK3B | |
| SCHEMBL3588854 | 0.78 | PDGFRB (0.47) | SYKEIF2AK4PDGFRACDK4CCND1 | |
| SCHEMBL1355980 | 0.78 | EIF2AK4 (0.61) | MAPK10SYKEIF2AK4TBK1MAPK8 | |
| SCHEMBL3573049 | 0.75 | CDK1 (0.46) | EIF2AK4ACVR1CDK4CCND1CCND2 | |
| SCHEMBL3581836 | 0.75 | CDK4 (0.49) | MAPK8GSK3BCDK4CCND1CCND2 | |
| SCHEMBL3583207 | 0.74 | ROCK1 (0.38) | MAPK10EIF2AK4GSK3AGSK3BCDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100190787-A1 | Modulators of Mitotic Kinases | BIOGEN IDEC MA INC | 2010-07-29 | — | — | US | claimed |
| US-20100190787-A1 | Modulators of Mitotic Kinases | BIOGEN IDEC MA INC | 2010-07-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100190787-A1 | Modulators of Mitotic Kinases | CDK1, BUB1, BUB1B | MAPK10 165/4885SYK 1222/4885EIF2AK4 998/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.