Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 2/20 | 0.44 |
| ▸ | LCK | P06239 | 8/20 | 0.43 |
| ▸ | LYN | P07948 | 8/20 | 0.43 |
| ▸ | SRC | P12931 | 8/20 | 0.43 |
| ▸ | KDR | P35968 | 8/20 | 0.43 |
| ▸ | INSR | P06213 | 7/20 | 0.43 |
| ▸ | HCK | P08631 | 7/20 | 0.43 |
| ▸ | BRAF | P15056 | 10/20 | 0.41 |
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
| ▸ | ARAF | P10398 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9970969 | 0.99 | CSF1R (0.44) | CSF1RLCKLYNSRCKDR | |
| SCHEMBL9970892 | 0.96 | CSF1R (0.45) | CSF1RLCKLYNSRCKDR | |
| SCHEMBL3580159 | 0.91 | CSF1R (0.46) | CSF1RLCKLYNSRCKDR | |
| SCHEMBL3587610 | 0.89 | CSF1R (0.46) | CSF1RLCKLYNSRCKDR | |
| SCHEMBL14218733 | 0.88 | CSF1R (0.45) | CSF1RLCKLYNSRCKDR | |
| SCHEMBL3585833 | 0.88 | CSF1R (0.51) | CSF1RLCKLYNSRCKDR | |
| SCHEMBL3586278 | 0.88 | CSF1R (0.51) | CSF1RBRAF | |
| SCHEMBL14218840 | 0.87 | BRAF (0.50) | CSF1RBRAF | |
| SCHEMBL3598962 | 0.87 | CSF1R (0.46) | CSF1RLCKLYNSRCKDR | |
| SCHEMBL3583324 | 0.87 | CSF1R (0.46) | CSF1RLCKLYNSRCKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8202876-B2 | Compounds and compositions as protein kinase inhibitors | IRM LLC (BM) | 2012-06-19 | — | — | US | claimed |
| US-20100029605-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2010-02-04 | — | — | US | claimed |
| EP-2057146-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2009-05-13 | — | — | EP | claimed |
| WO-2008042639-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2008-04-10 | — | — | WO | claimed |
| US-8202876-B2 | Compounds and compositions as protein kinase inhibitors | IRM LLC (BM) | 2012-06-19 | — | — | US | disclosed |
| US-20100029605-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2010-02-04 | — | — | US | disclosed |
| EP-2057146-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2009-05-13 | — | — | EP | disclosed |
| WO-2008042639-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2008-04-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029605-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | FYN, ABL2, LCK | CSF1R 476/4885LCK 3/4885LYN 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.