Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 1/20 | 0.36 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.36 |
| ▸ | P4HB | P07237 | 1/20 | 0.32 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.30 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.30 |
| ▸ | CTSK | P43235 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18182125 | 0.96 | CYP4F2 (0.37) | CYP4F2CYP4A11P4HBNR3C1L3MBTL1 | |
| SCHEMBL1975183 | 0.86 | USP2 (0.37) | CYP4F2CYP4A11P4HBNR3C1L3MBTL1 | |
| SCHEMBL3589272 | 0.77 | CYP4F2 (0.34) | CYP4F2CYP4A11 | |
| SCHEMBL3296864 | 0.77 | CYP2C19 (0.44) | — | |
| SCHEMBL3301106 | 0.76 | MEN1 (0.37) | CYP4F2CYP4A11CTSK | |
| SCHEMBL3296902 | 0.75 | PPIA (0.32) | CYP4F2CYP4A11 | |
| SCHEMBL3292584 | 0.74 | PPIA (0.33) | CYP4F2CYP4A11DDB1CRBN | |
| SCHEMBL30736687 | 0.72 | CYP4F2 (0.41) | CYP4F2CYP4A11CTSK | |
| SCHEMBL3295173 | 0.71 | CYP4F2 (0.38) | CYP4F2CYP4A11CTSK | |
| SCHEMBL1764252 | 0.70 | CYP4F2 (0.42) | CYP4F2CYP4A11CTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7705020-B2 | Benzimidazolone carboxylic acid derivatives | PFIZER INC. (US) | 2010-04-27 | — | — | US | disclosed |
| US-7595329-B2 | Benzimidazolone carboxylic acid derivatives | PFIZER INC (US) | 2009-09-29 | — | — | US | disclosed |
| US-20080108660-A1 | Benzimidazolone Carboxylic Acid Derivatives | PFIZER INC | 2008-05-08 | — | — | US | disclosed |
| US-20050277671-A1 | Benzimidazolone carboxylic acid derivatives | PFIZER INC | 2005-12-15 | — | — | US | disclosed |
| US-20050277673-A1 | Benzimidazolone carboxylic acid derivatives | PFIZER JAPAN INC. (JP) | 2005-12-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050277673-A1 | Benzimidazolone carboxylic acid derivatives | HRH2, HRH4, GPR4 | CYP4F2 1097/4885CYP4A11 615/4885P4HB 4403/4885 |
| US-20050277671-A1 | Benzimidazolone carboxylic acid derivatives | HRH2, HRH4, GPR4 | CYP4F2 1097/4885CYP4A11 615/4885P4HB 4403/4885 |
| US-20080108660-A1 | Benzimidazolone Carboxylic Acid Derivatives | HRH2, HRH4, GPR4 | CYP4F2 1184/4885CYP4A11 672/4885P4HB 4429/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.