Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 4/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.59 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.59 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.59 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.59 |
| ▸ | DRD1 | P21728 | 3/20 | 0.59 |
| ▸ | DRD3 | P35462 | 3/20 | 0.59 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.59 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.59 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.59 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.59 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.59 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.59 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.59 |
| ▸ | HTR2A | P28223 | 1/20 | 0.59 |
| ▸ | HTR2C | P28335 | 1/20 | 0.59 |
| ▸ | HRH1 | P35367 | 1/20 | 0.59 |
| ▸ | HTR2B | P41595 | 1/20 | 0.59 |
| ▸ | CCR3 | P51677 | 3/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14593276 | 0.84 | MC4R (0.69) | MC4RCYP2D6CHRM2ADRA2ACHRM1 | |
| SCHEMBL25375773 | 0.82 | MC4R (0.62) | MC4RCYP2D6CHRM2ADRA2ACHRM1 | |
| SCHEMBL2843665 | 0.82 | MC4R (0.62) | MC4RCYP2D6CHRM2ADRA2ACHRM1 | |
| SCHEMBL9366351 | 0.81 | CYP2D6 (0.70) | MC4RCYP2D6CHRM2ADRA2ACHRM1 | |
| SCHEMBL12513620 | 0.81 | MC4R (0.65) | MC4RCYP2D6CHRM2ADRA2ACHRM1 | |
| SCHEMBL12437115 | 0.79 | MC4R (0.59) | MC4RCYP2D6CHRM2ADRA2ACHRM1 | |
| SCHEMBL1712239 | 0.79 | KCNA5 (0.49) | CYP2D6SLC6A2SLC6A4TSHRCYP2C19 | |
| SCHEMBL16226720 | 0.78 | SLC6A4 (0.68) | MC4RCYP2D6CHRM2ADRA2ACHRM1 | |
| SCHEMBL8671188 | 0.76 | CYP2D6 (0.66) | MC4RCYP2D6CHRM2ADRA2ACHRM1 | |
| SCHEMBL2962625 | 0.75 | OPRM1 (0.65) | MC4RCYP2D6CHRM2ADRA2ACHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100029636-A1 | Lck inhibitors | NOVARTIS AG (CH) | 2010-02-04 | — | — | US | disclosed |
| CN-101516888-A | Pyrazolo [1, 5-a] pyrimidine derivatives and their therapeutic use | NOVARTIS AG (CH) | 2009-08-26 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029636-A1 | Lck inhibitors | LCK, ZAP70, FYN | MC4R 3945/4885CYP2D6 2093/4885CHRM2 4523/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.