Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | MEN1 | O00255 | 8/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.58 |
| ▸ | NPC1 | O15118 | 6/20 | 0.58 |
| ▸ | RAB9A | P51151 | 5/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.54 |
| ▸ | RELA | Q04206 | 1/20 | 0.54 |
| ▸ | NAMPT | P43490 | 1/20 | 0.53 |
| ▸ | CASP3 | P42574 | 1/20 | 0.52 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL321164 | 0.98 | MAPT (0.58) | MAPTALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL4945166 | 0.87 | CASR (0.65) | MAPTALDH1A1MEN1KMT2AHTT | |
| SCHEMBL3557866 | 0.84 | MAPT (0.59) | MAPTALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL1912292 | 0.84 | CNR1 (0.65) | MAPTALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL27439714 | 0.84 | MAPT (0.57) | MAPTALDH1A1MEN1KMT2ANPC1 | |
| Hydrochloric Acid SCHEMBL320265 | 0.81 | CASR (0.66) | MAPTALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL7157554 | 0.81 | EPHX1 (0.67) | MAPTALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL12808474 | 0.80 | CNR1 (0.58) | MAPTALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL21659729 | 0.80 | POLB (0.68) | MAPTALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL12995581 | 0.80 | CNR1 (0.50) | MAPTALDH1A1MEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2013211-B1 | PURINE DERIVATIVES FOR USE AS ADENOSIN A2A RECEPTOR AGONISTS | NOVARTIS AG (CH) | 2012-03-14 | — | — | EP | disclosed |