Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 5/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 5/20 | 0.34 |
| ▸ | IDH1 | O75874 | 5/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.33 |
| ▸ | KIT | P10721 | 1/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.32 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3592686 | 0.83 | MEN1 (0.36) | MEN1KMT2AALDH1A1 | |
| SCHEMBL21326695 | 0.77 | HSP90AB1 (0.38) | PDGFRBPDGFRAHSP90AB1MEN1MAPT | |
| SCHEMBL3149241 | 0.77 | ALOX15 (0.48) | PDGFRBPDGFRAMEN1MAPTKMT2A | |
| SCHEMBL3153818 | 0.76 | NPC1 (0.45) | MALT1HSP90AB1MAPTKMT2AALDH1A1 | |
| SCHEMBL3162591 | 0.75 | TSHR (0.43) | MALT1MAPTMTNR1AMTNR1BALDH1A1 | |
| SCHEMBL3149520 | 0.75 | TSHR (0.36) | HSP90AB1MEN1KMT2A | |
| SCHEMBL23273501 | 0.75 | HSP90AB1 (0.38) | HSP90AB1MEN1MAPTKMT2AALDH1A1 | |
| SCHEMBL29737883 | 0.75 | HSP90AB1 (0.38) | HSP90AB1MEN1MAPTKMT2AALDH1A1 | |
| Hydrochloric Acid SCHEMBL31147900 | 0.73 | HSP90AB1 (0.37) | HSP90AB1MEN1MAPTKMT2AALDH1A1 | |
| SCHEMBL3234849 | 0.73 | PDGFRB (0.37) | PDGFRBPDGFRAMALT1KITMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2081937-B1 | TRIAZOLOPYRIDAZINE PROTEIN KINASE MODULATORS | SGX PHARMACEUTICALS INC (US) | 2012-09-12 | — | — | EP | disclosed |
| US-8071581-B2 | Triazolopyridazine protein kinase modulators | SGX PHARMACEUTICALS, INC. (US) | 2011-12-06 | — | — | US | disclosed |
| US-20100120739-A1 | TRIAZOLOPYRIDAZINE PROTEIN KINASE MODULATORS | SGX PHARMACEUTICALS, INC. | 2010-05-13 | — | — | US | disclosed |
| CN-101558070-A | Triazolopyridazine protein kinase modulators | SGX PHARMACEUTICALS INC (US) | 2009-10-14 | — | — | CN | disclosed |
| EP-2081937-A2 | TRIAZOLOPYRIDAZINE PROTEIN KINASE MODULATORS | SGX Pharmaceuticals, Inc. (US) | 2009-07-29 | — | — | EP | disclosed |
| WO-2008051805-A2 | TRIAZOLO-PYRIDAZINE PROTEIN KINASE MODULATORS | SGX PHARMACEUTICALS, INC. (US) | 2008-05-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100120739-A1 | TRIAZOLOPYRIDAZINE PROTEIN KINASE MODULATORS | MAP4K5, MAPKAPK5, MAP4K2 | PDGFRB 1277/4885PDGFRA 1447/4885IDH1 1311/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.