Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 17/20 | 0.48 |
| ▸ | PARP2 | Q9UGN5 | 5/20 | 0.48 |
| ▸ | AURKA | O14965 | 2/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.40 |
| ▸ | TNKS | O95271 | 1/20 | 0.39 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.39 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.39 |
| ▸ | PARP12 | Q9H0J9 | 1/20 | 0.39 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.39 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.39 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL359741 | 0.93 | PARP1 (0.47) | PARP1PARP2AURKARPS6KB1TNKS | |
| SCHEMBL359165 | 0.87 | PARP1 (0.49) | PARP1PARP2AURKARPS6KB1TNKS | |
| SCHEMBL10172635 | 0.87 | PARP1 (0.45) | PARP1PARP2AURKARPS6KB1TNKS | |
| SCHEMBL358701 | 0.84 | PARP1 (0.47) | PARP1PARP2AURKARPS6KB1TNKS | |
| SCHEMBL359582 | 0.81 | PARP1 (0.48) | PARP1PARP2AURKARPS6KB1TNKS | |
| SCHEMBL359228 | 0.79 | PARP1 (0.48) | PARP1 | |
| SCHEMBL360311 | 0.78 | PARP1 (0.46) | PARP1PARP2AURKARPS6KB1TNKS | |
| SCHEMBL12503399 | 0.76 | PARP1 (0.37) | PARP1PARP2 | |
| SCHEMBL359421 | 0.75 | PARP1 (0.45) | PARP1 | |
| SCHEMBL10172411 | 0.74 | PARP1 (0.46) | PARP1PARP2AURKARPS6KB1TNKS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012006958-A1 | AMIDS SUBSTITUTED INDAZOLE DERIVATIVEES AS PLOY(ADP-RIBOSE)POLYMERASE INHIBITORS | ZHEJIANG BETA PHARMA INC. (CN) | 2012-01-19 | — | — | WO | claimed |
| WO-2012006958-A1 | AMIDS SUBSTITUTED INDAZOLE DERIVATIVEES AS PLOY(ADP-RIBOSE)POLYMERASE INHIBITORS | ZHEJIANG BETA PHARMA INC. (CN) | 2012-01-19 | — | — | WO | disclosed |
| WO-2012006958-A1 | AMIDS SUBSTITUTED INDAZOLE DERIVATIVEES AS PLOY(ADP-RIBOSE)POLYMERASE INHIBITORS | ZHEJIANG BETA PHARMA INC. (CN) | 2012-01-19 | — | — | WO | disclosed |