Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 7/20 | 0.48 |
| ▸ | JAK2 | O60674 | 12/20 | 0.44 |
| ▸ | JAK1 | P23458 | 12/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL359421 | 0.94 | PARP1 (0.45) | PARP1JAK2JAK1CYP11B2 | |
| SCHEMBL357957 | 0.89 | PARP1 (0.44) | PARP1JAK2JAK1CYP11B2 | |
| SCHEMBL359239 | 0.79 | PARP1 (0.51) | PARP1 | |
| SCHEMBL359452 | 0.79 | PARP1 (0.48) | PARP1 | |
| SCHEMBL28622929 | 0.78 | PARP1 (0.52) | PARP1JAK2JAK1 | |
| SCHEMBL359388 | 0.76 | PARP1 (0.50) | PARP1JAK2JAK1 | |
| SCHEMBL359741 | 0.75 | PARP1 (0.47) | PARP1 | |
| SCHEMBL359451 | 0.74 | PARP1 (0.51) | PARP1JAK2JAK1 | |
| SCHEMBL10172635 | 0.73 | PARP1 (0.45) | PARP1 | |
| SCHEMBL358670 | 0.72 | PARP1 (0.52) | PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012006958-A1 | AMIDS SUBSTITUTED INDAZOLE DERIVATIVEES AS PLOY(ADP-RIBOSE)POLYMERASE INHIBITORS | ZHEJIANG BETA PHARMA INC. (CN) | 2012-01-19 | — | — | WO | disclosed |