Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 6/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | BCHE | P06276 | 6/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL4886690 | 1.00 | KDM4E (0.60) | KDM4EHTTBCHEACHE | |
| Bromide SCHEMBL3587002 | 1.00 | KDM4E (0.60) | KDM4EHTTBCHEACHE | |
| Bromide SCHEMBL29415454 | 1.00 | KDM4E (0.60) | KDM4EHTTBCHEACHE | |
| SCHEMBL3597183 | 0.98 | KDM4E (0.57) | KDM4EHTTBCHEACHE | |
| SCHEMBL3595417 | 0.98 | KDM4E (0.57) | KDM4EHTTBCHEACHE | |
| SCHEMBL3600673 | 0.98 | KDM4E (0.57) | KDM4EHTTBCHEACHE | |
| SCHEMBL4891742 | 0.98 | KDM4E (0.57) | KDM4EHTTBCHEACHE | |
| SCHEMBL3599334 | 0.98 | KDM4E (0.57) | KDM4EHTTBCHEACHE | |
| SCHEMBL3595598 | 0.98 | KDM4E (0.57) | KDM4EHTTBCHEACHE | |
| Bromide SCHEMBL25407564 | 0.96 | KDM4E (0.55) | KDM4EHTTBCHEACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8546415-B2 | Bis-pyridino containing compounds for the use in the treatment of CNS pathologies | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2013-10-01 | — | — | US | disclosed |
| US-20100152237-A1 | BIS-PYRINDINO CONTAINING COMPOUNDS FOR THE USE IN THE TREATMENT OF CNS PATHOLOGIES | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2010-06-17 | — | — | US | disclosed |
| US-20080287490-A1 | Bis-pyridino containing compounds for the use in the treatment of CNS pathologies | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2008-11-20 | — | — | US | disclosed |
| US-20050261334-A1 | Bis-pyridino containing compounds for the use in the treatment of CNS pathologies | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION | 2005-11-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100152237-A1 | BIS-PYRINDINO CONTAINING COMPOUNDS FOR THE USE IN THE TREATMENT OF CNS PATHOLOGIES | SLC18A3, CHRNB2, CHRNB3 | ACHE 42/4885KDM4E 3882/4885HTT 713/4885 |
| US-20050261334-A1 | Bis-pyridino containing compounds for the use in the treatment of CNS pathologies | SLC18A3, SLC18A2, CHRNB2 | ACHE 43/4885KDM4E 2649/4885HTT 922/4885 |
| US-20080287490-A1 | Bis-pyridino containing compounds for the use in the treatment of CNS pathologies | SLC18A3, SLC18A2, CHRNB2 | ACHE 43/4885KDM4E 2649/4885HTT 922/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.