Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 3/20 | 0.71 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.71 |
| ▸ | PIM1 | P11309 | 3/20 | 0.71 |
| ▸ | PRKACA | P17612 | 3/20 | 0.71 |
| ▸ | CLK2 | P49760 | 3/20 | 0.71 |
| ▸ | GSK3B | P49841 | 3/20 | 0.71 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.71 |
| ▸ | PRKAA1 | Q13131 | 3/20 | 0.71 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.71 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.71 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.71 |
| ▸ | AXL | P30530 | 3/20 | 0.71 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.71 |
| ▸ | PRKCG | P05129 | 2/20 | 0.71 |
| ▸ | CDK1 | P06493 | 2/20 | 0.71 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.71 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.71 |
| ▸ | CDK2 | P24941 | 2/20 | 0.71 |
| ▸ | MARK3 | P27448 | 2/20 | 0.71 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3596684 | 0.90 | AURKB (0.56) | CHEK1MAP4K4PIM1PRKACACLK2 | |
| SCHEMBL3608525 | 0.84 | ROCK1 (0.79) | CHEK1MAP4K4PIM1PRKACACLK2 | |
| SCHEMBL3605135 | 0.83 | DYRK1A (1.00) | CHEK1MAP4K4PIM1PRKACACLK2 | |
| SCHEMBL3610317 | 0.83 | CHEK1 (0.62) | CHEK1MAP4K4PIM1PRKACACLK2 | |
| SCHEMBL1852515 | 0.82 | CHEK1 (0.84) | CHEK1MAP4K4PIM1PRKACACLK2 | |
| SCHEMBL3607698 | 0.79 | MAPK1 (0.42) | CHEK1MAP4K4PIM1PRKACACLK2 | |
| SCHEMBL3606604 | 0.78 | CDK2 (0.78) | CHEK1MAP4K4PIM1PRKACACLK2 | |
| SCHEMBL3603600 | 0.78 | CDK2 (0.78) | CHEK1MAP4K4PIM1PRKACACLK2 | |
| SCHEMBL3598686 | 0.78 | CHEK1 (0.74) | CHEK1MAP4K4PIM1PRKACACLK2 | |
| SCHEMBL3598684 | 0.78 | CHEK1 (0.74) | CHEK1MAP4K4PIM1PRKACACLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100035919-A1 | COMPOUNDS USEFUL AS INHIBITORS OF PROTEIN KINASES | ABBOTT LABORATORIES (US) | 2010-02-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100035919-A1 | COMPOUNDS USEFUL AS INHIBITORS OF PROTEIN KINASES | ROCK1, ROCK2, RHOA | CHEK1 434/4885MAP4K4 105/4885PIM1 820/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.