⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26100579 | 0.85 | CA1 (0.56) | — | |
| SCHEMBL12602390 | 0.77 | CA1 (0.65) | — | |
| SCHEMBL20557659 | 0.77 | — | — | |
| SCHEMBL20547768 | 0.74 | — | — | |
| SCHEMBL16657572 | 0.74 | — | — | |
| SCHEMBL2174072 | 0.74 | — | — | |
| SCHEMBL26106634 | 0.73 | KMT2A (0.71) | — | |
| SCHEMBL1742219 | 0.72 | — | — | |
| SCHEMBL2454896 | 0.69 | TLR4 (0.39) | — | |
| SCHEMBL9382717 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 81 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-120202258-A | Compositions and methods for reducing formaldehyde in acrylic or styrene-acrylic polymer products | 陶氏环球技术有限责任公司 | 2025-06-24 | — | — | CN | claimed |
| CN-120202258-A | Compositions and methods for reducing formaldehyde in acrylic or styrene-acrylic polymer products | 陶氏环球技术有限责任公司 | 2025-06-24 | — | — | CN | disclosed |
| US-20230158152-A1 | PROTEOLYSIS REGULATOR AND METHOD FOR USING SAME | MEDSHINE DISCOVERY INC. (CN) | 2023-05-25 | — | — | US | disclosed |
| US-11241430-B2 | Solid forms of 2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide, compositions thereof and methods of their use | SIGNAL PHARMACEUTICALS, LLC (US) | 2022-02-08 | — | — | US | disclosed |
| EP-3738954-A1 | METHOD OF PREPARATION OF SUBSTITUTED 2,4-DIAMINO-PYRIMIDINE-5-CARBOXAMIDES | Signal Pharmaceuticals, LLC (US) | 2020-11-18 | — | — | EP | disclosed |
| EP-3098222-B1 | FUSED ACRIDINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION, PREPARATION METHOD AND USE THEREOF | UNIV BEIJING (CN) | 2018-04-18 | — | — | EP | disclosed |
| EP-3098222-B1 | FUSED ACRIDINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION, PREPARATION METHOD AND USE THEREOF | UNIV BEIJING (CN) | 2018-04-18 | — | — | EP | disclosed |
| US-20180028534-A1 | SOLID FORMS OF 2-(TERT-BUTYLAMINO)-4-((1R,3R,4R)-3-HYDROXY-4-METHYLCYCLOHEXYLAMINO)-PYRIMIDINE-5-CARBOXAMIDE, COMPOSITIONS THEREOF AND METHODS OF THEIR USE | SIGNAL PHARM LLC (US) | 2018-02-01 | — | — | US | disclosed |
| US-9814713-B2 | Solid forms of 2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide, compositions thereof and methods of their use | SIGNAL PHARMACEUTICALS, LLC (US) | 2017-11-14 | — | — | US | disclosed |
| US-9814713-B2 | Solid forms of 2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide, compositions thereof and methods of their use | SIGNAL PHARMACEUTICALS, LLC (US) | 2017-11-14 | — | — | US | disclosed |
| US-4668799-A | Anti-hepatitis and anti-cirrhotic 1,3-dithiol-2-ylidene derivatives, and pharmaceutical compositions therefor | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1987-05-26 | — | — | US | disclosed |
| EP-0210284-A1 | 1,3-Dithiol-2-ylidene derivatives | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1987-02-04 | — | — | EP | disclosed |
| US-4546104-A | Pyrazolopyridine cycloalkanones and process for their preparation | ICI AMERICAS INC. (US) | 1985-10-08 | — | — | US | disclosed |
| EP-0141608-A2 | Pyrazolopyridine cycloalkanone derivatives | ICI AMERICAS INC. (US) | 1985-05-15 | — | — | EP | disclosed |
| US-4072660-A | FROM A 4-OXO-CARBOXYLIC ACID ESTER OR DELTA-ENOL-LACTONE AND STRONG BASE IN GLYCOL DIALKYL ETHER SOLVENT | HOECHST AKTIENGESELLSCHAFT (DT) | 1978-02-07 | — | — | US | disclosed |
| US-4028417-A | CARBOXYLIC OR PHOSPHORIC ACID AMIDES, SULFOXIDES OR SULFONES OR POLYOXYALKYLENE SOLVENTS | HOECHST AKTIENGESELLSCHAFT (DT) | 1977-06-07 | — | — | US | disclosed |
| US-3950438-A | Preparation of resorcinol and alkyl-substituted derivatives thereof | STAMICARBON B.V. (NL) | 1976-04-13 | — | — | US | disclosed |
| US-3947449-A | Tetrahydroacridones having chemotherapeutic action and process for preparing them | HOECHST AKTIENGESELLSCHAFT (DT) | 1976-03-30 | — | — | US | disclosed |
| US-3941828-A | Process for the preparation of cyclic ketones | FIRMENICH SA (CH) | 1976-03-02 | — | — | US | disclosed |
| US-3932511-A | Preparation of cyclohexane-1,3-dione and of alkyl-substituted derivatives thereof | STAMICARBON B.V. (NL) | 1976-01-13 | — | — | US | disclosed |