Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 5/20 | 0.49 |
| ▸ | AURKA | O14965 | 4/20 | 0.49 |
| ▸ | PARP1 | P09874 | 15/20 | 0.46 |
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL359585 | 0.93 | RPS6KB1 (0.47) | RPS6KB1AURKAPARP1PARP2 | |
| SCHEMBL359270 | 0.86 | PARP1 (0.49) | RPS6KB1AURKAPARP1PARP2 | |
| SCHEMBL359581 | 0.85 | RPS6KB1 (0.48) | RPS6KB1AURKAPARP1PARP2 | |
| SCHEMBL358323 | 0.84 | RPS6KB1 (0.44) | RPS6KB1AURKAPARP1PARP2 | |
| SCHEMBL358663 | 0.83 | RPS6KB1 (0.47) | RPS6KB1AURKAPARP1PARP2 | |
| Hydrochloric Acid SCHEMBL357948 | 0.82 | RPS6KB1 (0.48) | RPS6KB1AURKAPARP1PARP2 | |
| SCHEMBL358329 | 0.81 | PARP1 (0.46) | RPS6KB1AURKAPARP1PARP2 | |
| SCHEMBL359419 | 0.80 | PARP1 (0.40) | RPS6KB1AURKAPARP1PARP2 | |
| SCHEMBL359578 | 0.80 | PARP1 (0.47) | RPS6KB1AURKAPARP1PARP2 | |
| SCHEMBL359239 | 0.80 | PARP1 (0.51) | PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012006958-A1 | AMIDS SUBSTITUTED INDAZOLE DERIVATIVEES AS PLOY(ADP-RIBOSE)POLYMERASE INHIBITORS | ZHEJIANG BETA PHARMA INC. (CN) | 2012-01-19 | — | — | WO | claimed |
| WO-2012006958-A1 | AMIDS SUBSTITUTED INDAZOLE DERIVATIVEES AS PLOY(ADP-RIBOSE)POLYMERASE INHIBITORS | ZHEJIANG BETA PHARMA INC. (CN) | 2012-01-19 | — | — | WO | disclosed |
| WO-2012006958-A1 | AMIDS SUBSTITUTED INDAZOLE DERIVATIVEES AS PLOY(ADP-RIBOSE)POLYMERASE INHIBITORS | ZHEJIANG BETA PHARMA INC. (CN) | 2012-01-19 | — | — | WO | disclosed |