Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 15/20 | 0.46 |
| ▸ | PARP2 | Q9UGN5 | 6/20 | 0.45 |
| ▸ | PARP3 | Q9Y6F1 | 4/20 | 0.45 |
| ▸ | AURKA | O14965 | 5/20 | 0.41 |
| ▸ | RPS6KB1 | P23443 | 5/20 | 0.41 |
| ▸ | TNKS | O95271 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.40 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.40 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.40 |
| ▸ | PARP12 | Q9H0J9 | 1/20 | 0.40 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.40 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL359578 | 0.97 | PARP1 (0.47) | PARP1PARP2PARP3AURKARPS6KB1 | |
| SCHEMBL359495 | 0.86 | PARP1 (0.46) | PARP1PARP2PARP3AURKARPS6KB1 | |
| SCHEMBL358843 | 0.84 | PARP1 (0.44) | PARP1PARP2PARP3AURKARPS6KB1 | |
| SCHEMBL360334 | 0.83 | PARP1 (0.47) | PARP1PARP2PARP3AURKARPS6KB1 | |
| SCHEMBL359270 | 0.82 | PARP1 (0.49) | PARP1PARP2PARP3AURKARPS6KB1 | |
| SCHEMBL359589 | 0.81 | RPS6KB1 (0.49) | PARP1PARP2AURKARPS6KB1 | |
| SCHEMBL361151 | 0.81 | PARP1 (0.45) | PARP1PARP2PARP3AURKARPS6KB1 | |
| SCHEMBL359585 | 0.79 | RPS6KB1 (0.47) | PARP1PARP2PARP3AURKARPS6KB1 | |
| SCHEMBL358323 | 0.76 | RPS6KB1 (0.44) | PARP1PARP2PARP3AURKARPS6KB1 | |
| SCHEMBL12503322 | 0.75 | PARP1 (0.39) | PARP1PARP2PARP3AURKARPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012006958-A1 | AMIDS SUBSTITUTED INDAZOLE DERIVATIVEES AS PLOY(ADP-RIBOSE)POLYMERASE INHIBITORS | ZHEJIANG BETA PHARMA INC. (CN) | 2012-01-19 | — | — | WO | claimed |
| WO-2012006958-A1 | AMIDS SUBSTITUTED INDAZOLE DERIVATIVEES AS PLOY(ADP-RIBOSE)POLYMERASE INHIBITORS | ZHEJIANG BETA PHARMA INC. (CN) | 2012-01-19 | — | — | WO | disclosed |
| WO-2012006958-A1 | AMIDS SUBSTITUTED INDAZOLE DERIVATIVEES AS PLOY(ADP-RIBOSE)POLYMERASE INHIBITORS | ZHEJIANG BETA PHARMA INC. (CN) | 2012-01-19 | — | — | WO | disclosed |