Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.38 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3544080 | 0.92 | KDM4E (0.49) | MAPTKDM4EGAATSHRMAPK1 | |
| SCHEMBL30038200 | 0.92 | KDM4E (0.49) | MAPTKDM4EGAATSHRMAPK1 | |
| SCHEMBL9367414 | 0.88 | GAA (0.40) | MAPTKDM4EGAATSHRMAPK1 | |
| SCHEMBL20681623 | 0.87 | MAPT (0.51) | MAPTKDM4EGAATSHRMAPK1 | |
| SCHEMBL77823 | 0.81 | KDM4E (0.67) | MAPTKDM4EGAATSHRMAPK1 | |
| SCHEMBL29377777 | 0.81 | KDM4E (0.67) | MAPTKDM4EGAATSHRMAPK1 | |
| SCHEMBL2438047 | 0.81 | KDM4E (0.67) | MAPTKDM4EGAATSHRMAPK1 | |
| Methane SCHEMBL27340305 | 0.79 | KDM4E (0.64) | MAPTKDM4EGAATSHRMAPK1 | |
| Ammonia Solution, Strong SCHEMBL5361377 | 0.79 | KDM4E (0.64) | MAPTKDM4EGAATSHRMAPK1 | |
| Hydrochloric Acid SCHEMBL2479850 | 0.79 | MAPT (0.70) | MAPTKDM4EGAATSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210163448-A1 | QUINOLINE DERIVATIVES AS INHIBITORS OF AXL/MER RTK AND CSF1R | QURIENT CO., LTD. (KR) | 2021-06-03 | — | — | US | disclosed |
| US-10786484-B2 | Mono- or di-substituted indole derivatives as dengue viral replication inhibitors | Janssen Pharmaceuticals, Inc. (US) | 2020-09-29 | — | — | US | disclosed |
| US-8293916-B2 | Diazole derivatives | HOFFMANN-LA ROCHE INC. (US) | 2012-10-23 | — | — | US | disclosed |
| US-20100048569-A1 | DIAZOLE DERIVATIVES | BUETTELMANN BERND | 2010-02-25 | — | — | US | disclosed |
| EP-1756086-B1 | PYRIDIN-4-YL-ETHYNYL-IMIDAZOLES AND PYRAZOLES AS MGLU5 RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2008-06-04 | — | — | EP | disclosed |
| EP-1756086-A1 | PYRIDIN-4-YL-ETHYNYL-IMIDAZOLES AND PYRAZOLES AS MGLU5 RECEPTOR ANTAGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-02-28 | — | — | EP | disclosed |
| US-20060030559-A1 | Diazole derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2006-02-09 | — | — | US | disclosed |
| WO-2005118568-A1 | PYRIDIN-4-YL-ETHYNYL-IMIDAZOLES AND PYRAZOLES AS MGLU5 RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-15 | — | — | WO | disclosed |
| EP-0788491-B1 | 6-POLYFLUOROALKOXY AND 6-POLYFLUOROALKYL-2-AMINOBENZOTHIAZOLE DERIVATIVES | RHONE POULENC RORER SA (FR) | 1999-12-01 | — | — | EP | disclosed |
| US-5795903-A | 6-polyfluoroalkoxy-and 6-polyfluoroalkyl-2-aminobenzothiazole derivatives | RHONE-POULENC RORER S.A. (FR) | 1998-08-18 | — | — | US | disclosed |
| EP-0788491-A1 | 6-POLYFLUOROALKOXY AND 6-POLYFLUOROALKYL-2-AMINOBENZOTHIAZOLE DERIVATIVES | Aventis Pharma S.A. (FR) | 1997-08-13 | — | — | EP | disclosed |
| WO-1996013492-A1 | 6-POLYFLUOROALKOXY AND 6-POLYFLUOROALKYL-2-AMINOBENZOTHIAZOLE DERIVATIVES | RHONE-POULENC RORER S.A. (FR) | 1996-05-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10786484-B2 | Mono- or di-substituted indole derivatives as dengue viral replication inhibitors | IDO1, IDO2, IRF3 | MAPT 2171/4885KDM4E 697/4885GAA 3499/4885 |
| US-20100048569-A1 | DIAZOLE DERIVATIVES | GRM1, GRM2, GRIN2B | MAPT 1397/4885KDM4E 2704/4885GAA 1279/4885 |
| US-20060030559-A1 | Diazole derivatives | GRM1, GRM2, GRIN2B | MAPT 1397/4885KDM4E 2704/4885GAA 1279/4885 |
| US-20210163448-A1 | QUINOLINE DERIVATIVES AS INHIBITORS OF AXL/MER RTK AND CSF1R | CSF1R, CSF3R, FLT3 | MAPT 341/4885KDM4E 1909/4885GAA 1918/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.