SCHEMBL77823

SCHEMBL77823

COc1ccc(N)cc1OC

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 4/20 0.67
MAPT P10636 4/20 0.67
GAA P10253 2/20 0.67
TSHR P16473 4/20 0.61
MAPK1 P28482 2/20 0.61
HTT P42858 1/20 0.61
CYP19A1 P11511 3/20 0.61
NR4A1 P22736 1/20 0.59
ALDH1A1 P00352 6/20 0.57
USP2 O75604 1/20 0.57
LMNA P02545 1/20 0.55
CA2 P00918 2/20 0.54
ACHE P22303 1/20 0.54
CA12 O43570 1/20 0.54
CA1 P00915 1/20 0.54
CA7 P43166 1/20 0.54
CA9 Q16790 1/20 0.54
CA14 Q9ULX7 1/20 0.54
ATM Q13315 1/20 0.54
NR3C1 P04150 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2438047 1.00 KDM4E (0.67) KDM4EMAPTGAATSHRMAPK1
SCHEMBL29377777 1.00 KDM4E (0.67) KDM4EMAPTGAATSHRMAPK1
Hydrochloric Acid SCHEMBL2479850 0.97 MAPT (0.70) KDM4EMAPTGAATSHRMAPK1
Methane SCHEMBL27340305 0.97 KDM4E (0.64) KDM4EMAPTGAATSHRMAPK1
Ammonia Solution, Strong SCHEMBL5361377 0.97 KDM4E (0.64) KDM4EMAPTGAATSHRMAPK1
Hydroxyamine SCHEMBL4369811 0.95 KDM4E (0.62) KDM4EMAPTGAATSHRMAPK1
SCHEMBL27479772 0.89 KDM4E (0.56) KDM4EMAPTGAATSHRMAPK1
Ethylene Glycol SCHEMBL10464978 0.89 KDM4E (0.61) KDM4EMAPTGAATSHRMAPK1
SCHEMBL8526532 0.89 TDP1 (0.67) KDM4EMAPTGAATSHRMAPK1
Formic Acid SCHEMBL28246286 0.87 ALDH1A1 (0.55) KDM4EMAPTGAATSHRMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 3528 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4658271-A1 IMPROVED CABOZANTINIB COMPOSITIONS AND METHODS OF USE Handa Oncology, LLC (US) 2025-12-10 EP claimed
EP-4557952-A1 TRIGEMINAL CUE FOR WILDLIFE REPELLENTS The United States of America, as represented by the Secretary of Agriculture (US) 2025-05-28 EP claimed
WO-2024163400-A1 IMPROVED CABOZANTINIB COMPOSITIONS AND METHODS OF USE HANDA ONCOLOGY, LLC (US) 2024-08-08 WO claimed
CN-115322163-B Dicarboxamido tetrazine compound as VEGFR-2 inhibitor and preparation and application thereof 浙江工业大学 2024-04-09 CN claimed
CN-117586206-A Pterocarpus stilbene piperidine amide derivative, preparation method and medical application thereof 安徽中医药大学 2024-02-23 CN claimed
US-20240023546-A1 TRIGEMINAL CUE FOR WILDLIFE REPELLENTS THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (US) 2024-01-25 US claimed
WO-2024020079-A1 TRIGEMINAL CUE FOR WILDLIFE REPELLENTS THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (US) 2024-01-25 WO claimed
CN-117383994-A Preparation method of asymmetric urea compound and asymmetric urea compound 内蒙古工业大学 2024-01-12 CN claimed
CN-115322163-A Di-methylamino-s-tetrazine compound as VEGFR-2 inhibitor and preparation and application thereof 浙江工业大学 2022-11-11 CN claimed
CN-111621002-B Non-ionic waterborne epoxy resin curing agent and preparation method thereof 四川职业技术学院 2022-09-27 CN claimed
US-5874443-A BIOSYNTHESIS TREGA BIOSCIENCES, INC. (US) 1999-02-23 US claimed
EP-0884367-A2 Cationic diphenylamine dyestuffs and their anhydrobases BAYER AG (DE) 1998-12-16 EP claimed
EP-0863877-A1 ISOQUINOLINE DERIVATIVES AND ISOQUINOLINE COMBINATORIAL LIBRARIES TORREY PINES INSTITUTE FOR MOLECULAR STUDIES (US) 1998-09-16 EP claimed
WO-1997016428-A1 ISOQUINOLINE DERIVATIVES AND ISOQUINOLINE COMBINATORIAL LIBRARIES TORREY PINES INSTITUTE FOR MOLECULAR STUDIES (US) 1997-05-09 WO claimed
US-5464625-A Non-toxic methods of repelling rodents from materials susceptible to rodent consumption MONELL CHEMICAL SENSES CENTER (US) 1995-11-07 US claimed
EP-0322643-B1 MEDICINES CONTAINING AS A MIXTURE INTERFERON AND 1-DESOXY-PIPERIDINOSES, PROCESS FOR THEIR MANUFACTURE AND THEIR USE BAYER AG (DE) 1991-07-24 EP claimed
EP-0146642-B1 PROCESS FOR THE PREPARATION OF 4-AMINO-6,7-DIMETHOXY-2-(4-(FUROYL-2)-PIPERAZIN-1-YL)-QUINAZOLINE AND ITS PHYSIOLOGICALLY ACCEPTABLE SALT LUDWIG HEUMANN & CO GMBH (DE) 1988-01-20 EP claimed
CN-85103112-A Oxide hair dye based on the low viscosity carrier material 1986-10-22 CN claimed
EP-0146642-A1 Process for the preparation of 4-amino-6,7-dimethoxy-2-(4-(furoyl-2)-piperazin-1-yl)-quinazoline and its physiologically acceptable salt LUDWIG HEUMANN & CO GMBH (DE) 1985-07-03 EP claimed
US-4076537-A Light-sensitive materials containing organo tellurium or selenium compounds and sensitizers FUJI PHOTO FILM CO., LTD. (JA) 1978-02-28 US claimed