Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.72 |
| ▸ | LMNA | P02545 | 2/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.72 |
| ▸ | HPGD | P15428 | 1/20 | 0.72 |
| ▸ | CYP1A1 | P04798 | 8/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 8/20 | 0.67 |
| ▸ | CYP1B1 | Q16678 | 8/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.67 |
| ▸ | APP | P05067 | 1/20 | 0.62 |
| ▸ | GSK3B | P49841 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.56 |
| ▸ | CTSL | P07711 | 1/20 | 0.56 |
| ▸ | CTSB | P07858 | 1/20 | 0.56 |
| ▸ | BCHE | P06276 | 1/20 | 0.55 |
| ▸ | GUSB | P08236 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3597959 | 1.00 | MAPT (0.72) | MAPTALDH1A1LMNAKMT2AHPGD | |
| SCHEMBL196922 | 0.84 | MAPT (1.00) | MAPTALDH1A1LMNAKMT2AHPGD | |
| SCHEMBL196923 | 0.84 | MAPT (1.00) | MAPTALDH1A1LMNAKMT2AHPGD | |
| SCHEMBL9567804 | 0.84 | MAPT (0.70) | MAPTALDH1A1LMNAKMT2AHPGD | |
| SCHEMBL3598076 | 0.83 | APP (0.64) | MAPTALDH1A1LMNAKMT2AHPGD | |
| SCHEMBL3598073 | 0.83 | APP (0.64) | MAPTALDH1A1LMNAKMT2AHPGD | |
| SCHEMBL10893208 | 0.82 | MAPT (0.75) | MAPTLMNAKMT2ACYP1B1CYP3A4 | |
| SCHEMBL29420130 | 0.82 | MAPT (0.75) | MAPTLMNAKMT2ACYP1B1CYP3A4 | |
| SCHEMBL626787 | 0.82 | MAPT (0.75) | MAPTLMNAKMT2ACYP1B1CYP3A4 | |
| SCHEMBL626785 | 0.82 | MAPT (0.75) | MAPTLMNAKMT2ACYP1B1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7795249-B2 | Certain pyrazoline derivatives with kinase inhibitory activity | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2010-09-14 | — | — | US | disclosed |
| EP-2125778-A1 | CERTAIN PYRAZOLINE DERIVATIVES WITH KINASE INHIBITORY ACTIVITY | Millennium Pharmaceuticals, Inc. (US) | 2009-12-02 | — | — | EP | disclosed |
| US-20080171754-A1 | Certain pyrazoline derivatives with kinase inhibitory activity | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2008-07-17 | — | — | US | disclosed |
| WO-2008079277-A1 | CERTAIN PYRAZOLINE DERIVATIVES WITH KINASE INHIBITORY ACTIVITY | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2008-07-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080171754-A1 | Certain pyrazoline derivatives with kinase inhibitory activity | MAP3K5, MAP4K5, MAP3K20 | MAPT 2375/4885ALDH1A1 3584/4885LMNA 2987/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.