Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Itraconazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 19/20 | 0.74 |
| ▸ | ABCG2 | Q9UNQ0 | 4/20 | 0.74 |
| ▸ | LMNA | P02545 | 3/20 | 0.74 |
| ▸ | CYP51A1 | Q16850 | 3/20 | 0.74 |
| ▸ | ABCB11 | O95342 | 3/20 | 0.74 |
| ▸ | CYP8B1 | Q9UNU6 | 3/20 | 0.74 |
| ▸ | FYN | P06241 | 2/20 | 0.74 |
| ▸ | MEN1 | O00255 | 2/20 | 0.74 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.74 |
| ▸ | MAPT | P10636 | 2/20 | 0.74 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.74 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.74 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.74 |
| ▸ | TACR1 | P25103 | 1/20 | 0.74 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.74 |
| ▸ | CCR4 | P51679 | 1/20 | 0.74 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.74 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.57 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Itraconazole SCHEMBL23934 | 0.86 | CYP3A4 (1.00) | CYP3A4ABCG2LMNACYP51A1ABCB11 | |
| Itraconazole SCHEMBL16984893 | 0.86 | CYP3A4 (1.00) | CYP3A4ABCG2LMNACYP51A1ABCB11 | |
| Itraconazole SCHEMBL18073409 | 0.86 | CYP3A4 (1.00) | CYP3A4ABCG2LMNACYP51A1ABCB11 | |
| Itraconazole SCHEMBL64913 | 0.86 | CYP3A4 (1.00) | CYP3A4ABCG2LMNACYP51A1ABCB11 | |
| Itraconazole SCHEMBL15948108 | 0.86 | CYP3A4 (1.00) | CYP3A4ABCG2LMNACYP51A1ABCB11 | |
| Itraconazole SCHEMBL14875797 | 0.86 | CYP3A4 (1.00) | CYP3A4ABCG2LMNACYP51A1ABCB11 | |
| Itraconazole SCHEMBL20464865 | 0.86 | CYP3A4 (1.00) | CYP3A4ABCG2LMNACYP51A1ABCB11 | |
| Itraconazole SCHEMBL18241650 | 0.86 | CYP3A4 (1.00) | CYP3A4ABCG2LMNACYP51A1ABCB11 | |
| Itraconazole SCHEMBL14875903 | 0.86 | CYP3A4 (1.00) | CYP3A4ABCG2LMNACYP51A1ABCB11 | |
| Itraconazole SCHEMBL14875705 | 0.86 | CYP3A4 (1.00) | CYP3A4ABCG2LMNACYP51A1ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 194 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9050253-B2 | Oleaginous pharmaceutical and cosmetic foam | FOAMIX PHARMACEUTICALS LTD. (IL) | 2015-06-09 | — | — | US | claimed |
| US-8703105-B2 | Oleaginous pharmaceutical and cosmetic foam | FOAMIX LTD. (IL) | 2014-04-22 | — | — | US | claimed |
| US-8518378-B2 | Oleaginous pharmaceutical and cosmetic foam | FOAMIX LTD. (IL) | 2013-08-27 | — | — | US | claimed |
| US-20130195769-A1 | OLEAGINOUS PHARMACEUTICAL AND COSMETIC FOAM | FOAMIX LTD. (IL) | 2013-08-01 | — | — | US | claimed |
| US-20110002857-A1 | OLEAGINOUS PHARMACEUTICAL AND COSMETIC FOAM | FOAMIX LTD. (IL) | 2011-01-06 | — | — | US | claimed |
| US-7700076-B2 | Penetrating pharmaceutical foam | FOAMIX, LTD. (IT) | 2010-04-20 | — | — | US | claimed |
| US-7682623-B2 | Pharmaceutical composition for topical application | FOAMIX LTD. (IL) | 2010-03-23 | — | — | US | claimed |
| US-20100040561-A9 | PENETRATING PHARMACEUTICAL FOAM | FOAMIX LTD. (IL) | 2010-02-18 | — | — | US | claimed |
| US-20090105791-A1 | LIGHT EMITTING MEDICAL GARMENT DEVICE, KIT AND METHOD OF USING | NEUROPHYSIOLOGICAL CONCEPTS LLC | 2009-04-23 | — | — | US | claimed |
| JP-2007503428-A | — | — | 2007-02-22 | — | — | JP | claimed |
| US-6994863-B2 | Pharmaceutical and cosmetic carrier and composition for topical application | FOAMIX LTD. (IL) | 2006-02-07 | — | — | US | claimed |
| US-6967023-B1 | solidifying agent consists of a long chain fatty alcohol having at least 15 carbon atoms in its backbone and a fatty acid having at least 18 carbons in its backbone; carrier is semi-solid at rest and liquefies upon application of shear forces | FOAMIX, LTD. (IL) | 2005-11-22 | — | — | US | claimed |
| US-20050074414-A1 | Penetrating pharmaceutical foam | FOAMIX LTD. (IL) | 2005-04-07 | — | — | US | claimed |
| US-20050069566-A1 | Alcohol-free drug or cosmetics carrier mixture of water, hydrophobic solvent, surfactant and gelling agent; oil in water emulsions | FOAMIX LTD. (IL) | 2005-03-31 | — | — | US | claimed |
| WO-2005018530-A2 | PENETRATING PHARMACEUTICAL FOAM | FOAMIX LTD. (US) | 2005-03-03 | — | — | WO | claimed |
| WO-2005011567-A2 | FOAM CARRIER CONTAINING AMPHIPHILIC COPOLYMERIC GELLING AGENT | FOAMIX LTD. (US) | 2005-02-10 | — | — | WO | claimed |
| JP-2003528821-A | — | — | 2003-09-30 | — | — | JP | claimed |
| US-20030157138-A1 | Dermatological application with solidified fat compositions | VYNE PHARMACEUTICALS LTD. (F/K/A FOAMIX PHARMACEUTICALS LTD.) | 2003-08-21 | — | — | US | claimed |
| EP-1250116-A1 | PHARMACEUTICAL AND COSMETIC CARRIER OR COMPOSITION FOR TOPICAL APPLICATION | Thixo Ltd. (IL) | 2002-10-23 | — | — | EP | claimed |
| WO-2001051014-A1 | PHARMACEUTICAL AND COSMETIC CARRIER OR COMPOSITION FOR TOPICAL APPLICATION | THIXO LTD (IL) | 2001-07-19 | — | — | WO | claimed |