Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.44 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.44 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.44 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.43 |
| ▸ | MELK | Q14680 | 2/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.43 |
| ▸ | BRAF | P15056 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | FYN | P06241 | 1/20 | 0.43 |
| ▸ | LYN | P07948 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.43 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.43 |
| ▸ | LATS1 | O95835 | 1/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3591016 | 0.87 | MAPK10 (0.50) | RPS6KA3RPS6KA2RPS6KA1FGFR1FLT1 | |
| SCHEMBL3606588 | 0.78 | CLK1 (0.44) | RPS6KA3AURKACHEK2CSNK1DFGFR1 | |
| SCHEMBL3599649 | 0.76 | CDK1 (0.44) | RPS6KA3AURKACHEK2CSNK1DFGFR1 | |
| SCHEMBL3603159 | 0.76 | CDK4 (0.48) | KDM4C | |
| SCHEMBL13977101 | 0.73 | MELK (0.56) | RPS6KA3RPS6KA2RPS6KA1ALKMELK | |
| SCHEMBL24596934 | 0.69 | CDC7 (0.76) | ALKFYNMAPKAPK2 | |
| SCHEMBL4192334 | 0.69 | MAPK14 (0.61) | MELKCHEK1BRAFAURKACHEK2 | |
| SCHEMBL28337260 | 0.69 | MELK (0.69) | RPS6KA3RPS6KA2RPS6KA1MELKCHEK1 | |
| SCHEMBL19137960 | 0.68 | DGAT1 (0.60) | BRAFAURKAFGFR1FLT1 | |
| SCHEMBL4183476 | 0.68 | CDC7 (0.67) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118102-B1 | TRICYCLIC INDOLES AND (4,5-DIHYDRO) INDOLES | NERVIANO MEDICAL SCIENCES SRL (IT) | 2013-06-12 | — | — | EP | disclosed |
| US-8207180-B2 | Tricyclic indoles and (4,5-dihydro) indoles | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-06-26 | — | — | US | disclosed |
| US-20100075998-A1 | TRICYCLIC INDOLES AND (4,5-DIHYDRO) INDOLES | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2010-03-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100075998-A1 | TRICYCLIC INDOLES AND (4,5-DIHYDRO) INDOLES | CDC7, CDK7, CDK17 | RPS6KA3 219/4885RPS6KA2 355/4885RPS6KA1 292/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.