Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Cyclohexanone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 known ✓ | P03372 | 1/20 | 0.31 |
| ▸ | TRIM24 | O15164 | 2/20 | 0.65 |
| ▸ | TRIM33 | Q9UPN9 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.65 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | PGR | P06401 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cyclohexanone SCHEMBL28536813 | 1.00 | TRIM24 (0.65) | TRIM24TRIM33ALDH1A1FFAR3LCK | |
| Cyclohexanone SCHEMBL9421237 | 1.00 | TRIM24 (0.65) | TRIM24TRIM33ALDH1A1FFAR3LCK | |
| Cycloheptanone SCHEMBL3602798 | 1.00 | TRIM24 (0.65) | TRIM24TRIM33ALDH1A1FFAR3LCK | |
| Cyclohexanone SCHEMBL28259728 | 0.97 | TRIM24 (0.61) | TRIM24TRIM33ALDH1A1FFAR3LCK | |
| Cyclopentanone SCHEMBL3600348 | 0.97 | TRIM24 (0.62) | TRIM24TRIM33ALDH1A1FFAR3LCK | |
| Cyclohexanone SCHEMBL2255977 | 0.95 | ALDH1A1 (0.58) | TRIM24TRIM33ALDH1A1FFAR3LCK | |
| Cyclohexanone SCHEMBL1071504 | 0.91 | TRIM24 (0.69) | TRIM24TRIM33ALDH1A1SMN1; SMN2KMT2A | |
| Cyclohexanone SCHEMBL15659452 | 0.88 | TRIM24 (0.65) | TRIM24TRIM33ALDH1A1SMN1; SMN2KMT2A | |
| Cyclohexanone SCHEMBL27491229 | 0.88 | TRIM24 (0.65) | TRIM24TRIM33ALDH1A1SMN1; SMN2KMT2A | |
| Cyclopentanone SCHEMBL8150513 | 0.88 | TRIM24 (0.67) | TRIM24TRIM33ALDH1A1SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 56 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103869622-B | Photosensitive composition for the black matrix in liquid crystal display device, the black matrix with the composition and the method for forming black matrix using the composition | 乐金显示有限公司 | 2019-06-11 | — | — | CN | claimed |
| CN-108586178-A | The manufacturing method of nitrile and its corresponding amine | 中国石油化工股份有限公司 | 2018-09-28 | — | — | CN | claimed |
| CN-104557610-B | Process for the manufacture of nitriles and their corresponding amines | 中国石油化工股份有限公司 | 2018-04-27 | — | — | CN | claimed |
| CN-105238259-A | Vacuum plating UV coating for PET plastic cement | DEYANG SENHUA COATING CHEMICAL CO LTD | 2016-01-13 | — | — | CN | claimed |
| EP-0688769-B1 | Method of preparation of the 2-coumaranone | CLARIANT FRANCE SA (FR) | 2000-03-22 | — | — | EP | claimed |
| US-5616733-A | VAPOR PHASE REACTION OF GLYOXYLIC ACID WITH CYCLOHEXANONE IN PRESENCE OF A DEHYDRATION CATALYST | SOCIETE FRANCAISE HOECHST (FR) | 1997-04-01 | — | — | US | claimed |
| CN-111349018-B | Process for fluorinating inorganic or organic compounds by direct fluorination | 福建永晶科技股份有限公司 | 2024-04-16 | — | — | CN | disclosed |
| US-11795138-B2 | Process of fluorinating inorganic compounds by direct fluorination | Fujian Yongjing Technology Co.,Ltd (CN) | 2023-10-24 | — | — | US | disclosed |
| US-20220135516-A1 | Process of Fluorinating Inorganic Compounds by Direct Fluorination | Fujian Yongjing Technology Co.,Ltd (CN) | 2022-05-05 | — | — | US | disclosed |
| WO-2021031432-A1 | PROCESS OF FLUORINATING INORGANIC OR ORGANIC COMPOUNDS BY DIRECT FLUORINATION | FUJIAN YONGJING TECHNOLOGY CO., LTD (CN) | 2021-02-25 | — | — | WO | disclosed |
| US-20210053911-A1 | Process of Fluorinating Inorganic or Organic Compounds by Direct Fluorination | FUJIAN YONGJING TECHNOLOGY CO., LTD (CN) | 2021-02-25 | — | — | US | disclosed |
| EP-3782969-A1 | PROCESS OF FLUORINATING INORGANIC OR ORGANIC COMPOUNDS BY DIRECT FLUORINATION | Fujian Yongjing Technology Co., Ltd. (CN) | 2021-02-24 | — | — | EP | disclosed |
| CN-111349018-A | Process for fluorinating inorganic or organic compounds by direct fluorination | 福建永晶科技股份有限公司 | 2020-06-30 | — | — | CN | disclosed |
| EP-0551138-B1 | Film for a light valve, and method for manufacturing the film | HANKUK GLASS IND INC (KR) | 1997-04-02 | — | — | EP | disclosed |
| US-5616733-A | VAPOR PHASE REACTION OF GLYOXYLIC ACID WITH CYCLOHEXANONE IN PRESENCE OF A DEHYDRATION CATALYST | SOCIETE FRANCAISE HOECHST (FR) | 1997-04-01 | — | — | US | disclosed |
| US-5488601-A | Photoelectric sensor, information recording system, and information recording method | DAI NIPPON PRINTING CO., LTD. (JP) | 1996-01-30 | — | — | US | disclosed |
| EP-0551138-A1 | Film for a light valve, and method for manufacturing the film | HANKUK GLASS INDUSTRIES, INC. (KR) | 1993-07-14 | — | — | EP | disclosed |
| EP-0307077-A1 | Tetrahydrocarbazoles for the improvement of cyclosporin therapy | MERCK FROSST CANADA INC. (CA) | 1989-03-15 | — | — | EP | disclosed |
| EP-0001498-A1 | Abrasion resistant coating compositions and substrates and laminates coated therewith | MONSANTO COMPANY (US) | 1979-04-18 | — | — | EP | disclosed |
| US-4115622-A | POLYVINYL ACETAL RESIN, FLUORINATED ALCOHOL, POLYSILIC ACID | MONSANTO COMPANY (US) | 1978-09-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11795138-B2 | Process of fluorinating inorganic compounds by direct fluorination | AFF2, CYP4F2, AFF1 | ESR1 1446/4885TRIM24 3607/4885TRIM33 2928/4885 |
| US-20210053911-A1 | Process of Fluorinating Inorganic or Organic Compounds by Direct Fluorination | CYP4F2, AFF2, CYP4F3 | ESR1 1751/4885TRIM24 3323/4885TRIM33 2627/4885 |
| US-20220135516-A1 | Process of Fluorinating Inorganic Compounds by Direct Fluorination | AFF2, CYP4F2, AFF1 | ESR1 1446/4885TRIM24 3607/4885TRIM33 2928/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.