Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.48 |
| ▸ | DRD4 | P21917 | 1/20 | 0.45 |
| ▸ | SMYD3 | Q9H7B4 | 4/20 | 0.41 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.41 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.40 |
| ▸ | NSD2 | O96028 | 1/20 | 0.39 |
| ▸ | SETD2 | Q9BYW2 | 1/20 | 0.39 |
| ▸ | PBK | Q96KB5 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3600317 | 1.00 | MAPK1 (0.48) | MAPK1OPRK1DRD4SMYD3HTR4 | |
| SCHEMBL3605929 | 0.94 | MAPK1 (0.57) | MAPK1OPRK1DRD4SMYD3PBK | |
| SCHEMBL3605925 | 0.94 | MAPK1 (0.57) | MAPK1OPRK1DRD4SMYD3PBK | |
| Trifluoroacetic Acid SCHEMBL3611914 | 0.93 | MAPK1 (0.43) | MAPK1OPRK1DRD4SMYD3HTR4 | |
| SCHEMBL3599694 | 0.82 | HDAC3 (0.51) | MAPK1OPRK1DRD4SMYD3HTR4 | |
| SCHEMBL3599696 | 0.82 | HDAC3 (0.51) | MAPK1OPRK1DRD4SMYD3HTR4 | |
| SCHEMBL3610362 | 0.81 | KDM4E (0.56) | HTR4KMT2ARAB9AL3MBTL1 | |
| SCHEMBL3610359 | 0.81 | KDM4E (0.56) | HTR4KMT2ARAB9AL3MBTL1 | |
| SCHEMBL3611688 | 0.81 | MAPK1 (0.51) | MAPK1OPRK1DRD4SMYD3HTR4 | |
| SCHEMBL3612648 | 0.81 | MAPK1 (0.51) | MAPK1OPRK1DRD4SMYD3HTR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100035862-A1 | NOVEL AZA-CYCLIC INDOLE-2-CARBOXAMIDES AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2010-02-11 | — | — | US | claimed |
| US-20100035862-A1 | NOVEL AZA-CYCLIC INDOLE-2-CARBOXAMIDES AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2010-02-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100035862-A1 | NOVEL AZA-CYCLIC INDOLE-2-CARBOXAMIDES AND METHODS OF USE THEREOF | IDO2, IDO1, INMT | MAPK1 4292/4885OPRK1 609/4885DRD4 2343/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.