Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | HSD17B2 | P37059 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | GCGR | P47871 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | KIF5B | P33176 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3612443 | 0.83 | HSD17B2 (0.40) | SMN1; SMN2POLBMEN1KMT2ACYP1A2 | |
| SCHEMBL3617878 | 0.77 | HSD17B2 (0.36) | SMN1; SMN2POLBMEN1KMT2ACYP1A2 | |
| SCHEMBL3609583 | 0.77 | MAPT (0.43) | SMN1; SMN2POLBMEN1KMT2ACYP1A2 | |
| SCHEMBL31281467 | 0.66 | CA12 (0.58) | SMN1; SMN2CYP2C9HSD17B2TDP1LMNA | |
| SCHEMBL2239504 | 0.66 | CA12 (0.58) | SMN1; SMN2CYP2C9HSD17B2TDP1LMNA | |
| SCHEMBL3607355 | 0.66 | PTPN11 (0.35) | SMN1; SMN2POLBMEN1KMT2ACYP1A2 | |
| SCHEMBL3609034 | 0.66 | SMN1; SMN2 (0.36) | SMN1; SMN2POLBRAB9A | |
| SCHEMBL3614801 | 0.65 | NPSR1 (0.37) | SMN1; SMN2MEN1KMT2ACYP1A2CYP2C9 | |
| SCHEMBL19209446 | 0.64 | SMN1; SMN2 (0.51) | SMN1; SMN2POLBMEN1KMT2ACYP1A2 | |
| SCHEMBL30620468 | 0.62 | ACHE (0.50) | MEN1KMT2ACYP1A2CYP2C19HSD17B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100016396-A1 | PYRAZOLE COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-01-21 | — | — | US | disclosed |
| EP-2128138-A1 | PYRAZOLE COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2009-12-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100016396-A1 | PYRAZOLE COMPOUND | SLC5A1, SLC5A2, GLP1R | SMN1; SMN2 4515/4885POLB 3604/4885MEN1 2280/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.