Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Salsalate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACMSD | Q8TDX5 | 6/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.70 |
| ▸ | HPGD | P15428 | 3/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.70 |
| ▸ | TTR | P02766 | 2/20 | 0.70 |
| ▸ | DHFR | P00374 | 2/20 | 0.70 |
| ▸ | LMNA | P02545 | 2/20 | 0.70 |
| ▸ | MEN1 | O00255 | 1/20 | 0.70 |
| ▸ | USP2 | O75604 | 1/20 | 0.70 |
| ▸ | CA1 | P00915 | 1/20 | 0.70 |
| ▸ | CA2 | P00918 | 1/20 | 0.70 |
| ▸ | ALB | P02768 | 1/20 | 0.70 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.70 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.70 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.70 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.70 |
| ▸ | MCL1 | Q07820 | 8/20 | 0.47 |
| ▸ | HNF4A | P41235 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diflunisal SCHEMBL5602956 | 0.89 | ACMSD (0.70) | ACMSDHSD17B10KDM4EHPGDALDH1A1 | |
| Diflunisal SCHEMBL6277460 | 0.88 | ACMSD (0.86) | ACMSDHSD17B10KDM4EHPGDALDH1A1 | |
| Guacetisal SCHEMBL13724334 | 0.86 | KDM4E (0.60) | ACMSDHSD17B10KDM4EHPGDALDH1A1 | |
| Diflunisal SCHEMBL5603898 | 0.85 | KDM4E (0.55) | ACMSDHSD17B10KDM4EHPGDALDH1A1 | |
| Diflunisal SCHEMBL3848363 | 0.84 | ACMSD (1.00) | ACMSDHSD17B10KDM4EHPGDALDH1A1 | |
| Diflunisal SCHEMBL4337 | 0.84 | ACMSD (1.00) | ACMSDHSD17B10KDM4EHPGDALDH1A1 | |
| Diflunisal SCHEMBL29367380 | 0.84 | ACMSD (1.00) | ACMSDHSD17B10KDM4EHPGDALDH1A1 | |
| Diflunisal SCHEMBL30509654 | 0.84 | ACMSD (1.00) | ACMSDHSD17B10KDM4EHPGDALDH1A1 | |
| SCHEMBL5602861 | 0.84 | TTR (0.62) | ACMSDHSD17B10KDM4EHPGDALDH1A1 | |
| Diflunisal SCHEMBL20876816 | 0.83 | ACMSD (0.97) | ACMSDHSD17B10KDM4EHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114392360-A | Dendrimer compositions and use in the treatment of neurological and CNS disorders | 约翰霍普金斯大学 | 2022-04-26 | — | — | CN | disclosed |
| US-20210085665-A1 | FORMULATIONS OF 4-AMINO-2-(2,6-DIOXOPIPERIDINE-3-YL)ISOINDOLINE-1,3-DIONE | CELGENE CORP (US) | 2021-03-25 | — | — | US | disclosed |
| CN-106659798-A | Dendrimer compositions and use in the treatment of neurological and CNS disorders | 约翰霍普金斯大学 | 2017-05-10 | — | — | CN | disclosed |
| EP-2585043-A2 | A BIOACTIVE DOSE CONTAINING A MATERIAL FOR MODULATING PH OF A BODILY FLUID | Fuisz, Richard C. (US) | 2013-05-01 | — | — | EP | disclosed |
| WO-2012009144-A2 | A BIOACTIVE DOSE CONTAINING A MATERIAL FOR MODULATING PH OF A BODILY FLUID | FUISZ RICHARD C (US) | 2012-01-19 | — | — | WO | disclosed |
| EP-2205227-A1 | EXTRUDABLE AND EXTRUDED COMPOSITIONS FOR DELIVERY OF BIOACTIVE AGENTS, METHOD OF MAKING THE SAME AND METHOD OF USING SAME | Philip Morris Products S.A. (CH) | 2010-07-14 | — | — | EP | disclosed |
| EP-2107909-A2 | COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF LIVER DISORDERS | IDENIX Pharmaceuticals, Inc. (US) | 2009-10-14 | — | — | EP | disclosed |
| WO-2009048606-A1 | EXTRUDABLE AND EXTRUDED COMPOSITIONS FOR DELIVERY OF BIOACTIVE AGENTS, METHOD OF MAKING THE SAME AND METHOD OF USING SAME | FUISZ RICHARD C (US) | 2009-04-16 | — | — | WO | disclosed |
| WO-2008082602-A2 | COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF LIVER DISORDERS | IDENIX PHARMACEUTICALS, INC. (US) | 2008-07-10 | — | — | WO | disclosed |